120166-69-0

Basic information

• Product Name: DIACYLGLYCEROL KINASE INHIBITOR II
• Synonyms: DIACYLGLYCEROL KINASE INHIBITOR I (R59 949);DIACYLGLYCEROL KINASE INHIBITOR II;3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE;R59949;DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949);3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone;R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
• CAS NO: 120166-69-0
• Molecular Formula: C28H25F2N3OS
• Molecular Weight: 489.58
• Product Categories: quinazolinone
• Mol File: 120166-69-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 637.1 °C at 760 mmHg
• Flash Point: 339.1 °C
• Appearance: pale yellow/solid
• Density: 1.36 g/cm³
• Vapor Pressure: 3.94E-16mmHg at 25°C
• Refractive Index: 1.688
• Storage Temp.: −20°C
• Solubility: 0.1 M HCl: slightly soluble
• PKA: 11.24±0.20(Predicted)
• CAS DataBase Reference: DIACYLGLYCEROL KINASE INHIBITOR II(CAS DataBase Reference)
• NIST Chemistry Reference: DIACYLGLYCEROL KINASE INHIBITOR II(120166-69-0)
• EPA Substance Registry System: DIACYLGLYCEROL KINASE INHIBITOR II(120166-69-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 120166-69-0(Hazardous Substances Data)

Usage

Description

DIACYLGLYCEROL KINASE INHIBITOR II, also known as R-59-949, is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. It plays a crucial role in modulating various cellular processes, including signal transduction and cell proliferation.
Used in Pharmaceutical Industry:
DIACYLGLYCEROL KINASE INHIBITOR II is used as a research tool for studying the role of DGK-α in various cellular processes and its potential as a therapeutic target for different diseases.
Used in Cancer Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as a research compound for determining tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). This helps in understanding the potential of CAR-T cell therapy in cancer treatment.
Used in Leukemia Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as an experimental agent to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells. This aids in investigating the underlying mechanisms of T-ALL and exploring potential therapeutic strategies.
Used in Diabetes Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as an inhibitor to study the role of DGK-α in high K+and glucose-induced insulin secretion in MIN6 pancreatic β-cells. This helps in understanding the regulation of insulin secretion and its implications in diabetes management.
Used in Ophthalmology Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as a therapeutic agent to prevent retinal neovascularization in a mouse model of oxygen-induced retinopathy. This highlights its potential in treating retinal disorders and vascular abnormalities in the eye.

Biochem/physiol Actions

Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.

InChI:InChI=1/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)