1201902-04-6 Usage
Chemical class
Quinazoline derivative
Activity
Potential antineoplastic (anti-cancer) activity
Mechanism of action
Potent and selective inhibitor of the poly (ADP-ribose) polymerase (PARP) enzyme
Role in DNA repair
PARP enzyme plays a key role in DNA repair
Effect on cancer cells
Inhibiting PARP disrupts DNA repair, leading to the accumulation of DNA lesions and inducing apoptosis (cell death)
Preclinical studies
Shown promising anti-tumor activity
Potential use
Investigation for the treatment of various types of cancer
Check Digit Verification of cas no
The CAS Registry Mumber 1201902-04-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,1,9,0 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1201902-04:
(9*1)+(8*2)+(7*0)+(6*1)+(5*9)+(4*0)+(3*2)+(2*0)+(1*4)=86
86 % 10 = 6
So 1201902-04-6 is a valid CAS Registry Number.
1201902-04-6Relevant articles and documents
6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS
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Page/Page column 30, (2010/01/12)
The present invention is directed to 6-(1H-imidazo-1-yl)-2-aryl and 2-heteroaryl quinazoline and quinolines derivatives, compounds of formula (I), their pharmaceutical acceptable salts and solvates and corresponding pharmaceutical compositions, that acts
