1202059-62-8

Basic information

• Product Name: (2S,4R)-2-methyl-4-phenyl-2-trifluoromethyl-1,3-oxazolidine
• Synonyms: (2S,4R)-2-methyl-4-phenyl-2-trifluoromethyl-1,3-oxazolidine
• CAS NO: 1202059-62-8
• Molecular Weight: 231.218
• Mol File: 1202059-62-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,4R)-2-methyl-4-phenyl-2-trifluoromethyl-1,3-oxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-2-methyl-4-phenyl-2-trifluoromethyl-1,3-oxazolidine(1202059-62-8)
• EPA Substance Registry System: (2S,4R)-2-methyl-4-phenyl-2-trifluoromethyl-1,3-oxazolidine(1202059-62-8)

Safety Data

• Hazardous Substances Data: 1202059-62-8(Hazardous Substances Data)

Upstream product

• 1358465-38-9 (2S,4R)-2-trifluoromethyl-2-methyl-4-phenyl-3-propanoyloxazolidine 
• 1358465-35-6 (2R,4R)-2-methyl-2-trifluoromethyl-4-phenyloxazolidine 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 911411-55-7 (2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile 
• 911411-54-6 (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile 
• 1358465-22-1 (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine 
• 1358465-26-5 (2R,4R)-2-trifluoromethyl-2-methyl-3-[(S)-2-methylbutanoyl]-4-phenyloxazolidine 
• 1358465-28-7 (S)-2-methyl-N-(1-phenylvinyl)-3-phenylpropanamide 
• 1358465-29-8 (S)-2-methyl-N-(1-phenylvinyl)-butanamide 
• 1358465-34-5 (R)-2-(2,2,2-trifluoro-1-methylethylamino)-2-phenylethanol 
• 1358465-35-6 (2R,4R)-2-methyl-2-trifluoromethyl-4-phenyloxazolidine 
• 1358465-21-0 (2S,4R)-2-trifluoromethyl-2-methyl-3-[2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine 
• 1358465-41-4 (2R,4R)-2-trifluoromethyl-2-methyl-4-phenyl-3-propanoyloxazolidine 
• 1358465-38-9 (2S,4R)-2-trifluoromethyl-2-methyl-4-phenyl-3-propanoyloxazolidine 

Relevant articles and documents

2-Trifluoromethyl-2-methyl-4-phenyloxazolidine: A new chiral auxiliary for highly diastereoselective enolate alkylation

The alkylation reactions of an amide sodium enolate derived from a C-2 disubstituted trifluoromethylated oxazolidine (Fox) chiral auxiliary occurred in good yields with a very high diastereoselectivity (>98% de). Compared to the C-2 monosubstituted trifluoromethyl analogue, this chiral auxiliary is much more stable towards bases at temperature over -35 °C because the dehydrofluorination reaction is avoided. However asymmetric enolates quaternarization was not successfully achieved with this new chiral auxiliary.