1202077-80-2

Basic information

• Product Name: C₃₀H₂₉FN₄O₅S
• CAS NO: 1202077-80-2
• Molecular Weight: 576.648
• Mol File: 1202077-80-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₉FN₄O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₉FN₄O₅S(1202077-80-2)
• EPA Substance Registry System: C₃₀H₂₉FN₄O₅S(1202077-80-2)

Safety Data

• Hazardous Substances Data: 1202077-80-2(Hazardous Substances Data)

Upstream product

• 13726-67-5 N^α-(tert-butyloxycarbonyl)-D-aspartic acid 
• 1202077-98-2 C₂₁H₁₆FN₃S 
• 1202074-53-0 C₂₃H₁₅F₄N₃OS 
• 1202077-74-4 C₂₂H₁₄FN₅OS 
• 1360817-20-4 C₂₂H₁₄ClFN₂OS 
• 1202075-64-6 C₂₂H₁₅FN₂O₂S 
• 1202075-59-9 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde 

Downstream Products

• 1202074-61-0 C₂₅H₂₁FN₄O₃S 

Relevant articles and documents

Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups

Replacement of the azetidine carboxylate of an S1P1 agonist development candidate, AMG 369, with a range of acyclic head-groups led to the identification of a novel, S1P3-sparing S1P1 agonist, (-)-2-amino -4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl) phenyl)-2-methylbutanoic acid (8c), which possessed good in vivo efficacy and pharmacokinetic properties. A 0.3 mg/kg oral dose of 8c produced a statistically significant reduction in blood lymphocyte counts 24 h post-dosing in female Lewis rats.