120219-31-0

Basic information

• Product Name: L-N-(tert-butoxycarbonyl)serine phenacyl ester
• Synonyms: L-N-(tert-butoxycarbonyl)serine phenacyl ester
• CAS NO: 120219-31-0
• Molecular Weight: 323.346
• Mol File: 120219-31-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-N-(tert-butoxycarbonyl)serine phenacyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-N-(tert-butoxycarbonyl)serine phenacyl ester(120219-31-0)
• EPA Substance Registry System: L-N-(tert-butoxycarbonyl)serine phenacyl ester(120219-31-0)

Safety Data

• Hazardous Substances Data: 120219-31-0(Hazardous Substances Data)

Upstream product

• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 70-11-1 α-bromoacetophenone 
• 10342-06-0 Dicyclohexylammoniumsalz des N-Boc-Serins 

Downstream Products

• 945473-75-6 O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine phenacyl ester 
• 153737-35-0 Boc-Ser-OH 
• 945473-52-9 C₄₂H₆₅N₅O₁₂ 
• 766513-83-1 C₄₂H₆₇N₅O₁₃ 
• 766513-82-0 C₅₇H₇₉N₅O₁₅ 
• 945473-49-4 O-(L-N-(benzyloxycarbonyl)-N,O-dimethyltyrosyl)-N-(tert-butoxycarbonyl)-L-serine 
• 171775-79-4 Boc-Ser-OPac 

Relevant articles and documents

Total synthesis and biological evaluation of tamandarin B analogues

(Chemical Equation Presented) Tamandarins A and B are a class of marine natural cyclodepsipeptides with structures and biological activities closely related to those of the didemnins. The easier synthetic access to tamandarins accelerates the preparation of new macrocyclic derivatives of this family of antitumor, antiviral, and immunosuppressive compounds. The optimization of the previously reported synthetic route to tamandarins by changing the macrolactamization site from Nst1 and Thr6 to Pro 4 and N,O-Me2Tyr5 residues led to a significant improvement in the reaction yield. Using this new synthetic approach, four new macrocyclic analogues of tamandarin B were prepared and evaluated for anticancer activity. These results provide further insight into the structure-activity relationship of the tamandarins and didemnins.