1202362-65-9Relevant articles and documents
Synthesis and SAR study of a novel series of dopamine receptor agonists
Risgaard, Rune,Jensen, Martin,J?rgensen, Morten,Bang-Andersen, Benny,Christoffersen, Claus T.,Jensen, Klaus G.,Kristensen, Jesper L.,Püschl, Ask
, p. 381 - 392 (2014)
The synthesis of a novel series of dopamine receptor agonists are described as well as their in vitro potency and efficacy on dopamine D1 and D2 receptors. This series was designed from pergolide and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-6-ol (PHBQ) and resulted in the synthesis of (2R,4aR,10aR)-2-methylsulfanylmethyl-4-propyl- 3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-9-ol (compound 27), which has a D1 and D2 receptor profile similar to that of the most recently approved drug for Parkinson's disease, rotigotine.
NOVEL PHENOLIC AND CATECHOLIC AMINES AND PRODRUGS THEREOF
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Page/Page column 39, (2010/01/30)
The present invention relates to novel phenolic and catecholic amines of Formula 1, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or SPECT Iigands.