1202897-48-0

Basic information

• Product Name: Methyl 5-fluoro-2-iodobenzoate
• Synonyms: Methyl 5-fluoro-2-iodobenzoate;Methyl 5-fluoro-2-iodobenzoate 97%;5-fluoro-2-iodobenzoic acid methyl ester;Methyl5-fluoro-2-iodobenzoate97%
• CAS NO: 1202897-48-0
• Molecular Formula: C8H6FIO2
• Molecular Weight: 280.0349132
• Mol File: 1202897-48-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 264.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.823±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Methyl 5-fluoro-2-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-fluoro-2-iodobenzoate(1202897-48-0)
• EPA Substance Registry System: Methyl 5-fluoro-2-iodobenzoate(1202897-48-0)

Safety Data

• Hazardous Substances Data: 1202897-48-0(Hazardous Substances Data)

Usage

Description

Methyl 5-fluoro-2-iodobenzoate is an organic compound that features a methyl ester group attached to a benzene ring, which is substituted with a fluorine atom at the 5th position and an iodine atom at the 2nd position. This unique structure endows it with specific chemical properties that make it a valuable intermediate in various synthetic processes.

Uses

Used in Pharmaceutical Industry:
Methyl 5-fluoro-2-iodobenzoate is used as a key reactant for the synthesis of arene-fused cyclic β-ketoesters. This application is crucial in the development of novel pharmaceutical compounds, as these β-ketoesters can serve as building blocks for the creation of complex molecular structures with potential therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, Methyl 5-fluoro-2-iodobenzoate is utilized as a versatile intermediate for the preparation of various organic compounds. Its unique substitution pattern allows for a range of reactions, including homoconjugate addition and decarboxylative Dieckmann cyclization, which can lead to the formation of complex and diverse molecular architectures.
Used in Chemical Research:
Methyl 5-fluoro-2-iodobenzoate also finds application in chemical research, where it can be employed to study the effects of different substituents on the reactivity and selectivity of organic reactions. This knowledge can be valuable for the development of new synthetic methods and the optimization of existing ones.

Upstream product

• 319-24-4 2-amino-5-fluoro-benzoic acid methyl ester 
• 67-56-1 methanol 
• 52548-63-7 5-fluoro-2-iodobenzoic acid 

Downstream Products

• 877264-44-3 5-fluoro-2-iodobenzaldehyde 
• 1247810-91-8 methyl 4-fluoro-[1,1'-biphenyl]-2-carboxylate 

Relevant articles and documents

F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.

CHEMICAL COMPOUNDS

The invention relates to a novel compound of formula (I) or a stereoisomer, or a racemate or a mixture or a pharmaceutically acceptable salt thereof: wherein: R is phenyl or a 5- or 6-membered heteroaryl ring containing 1 to 3 heteroatoms selected from S, N and O, such rings may be optionally substituted with n groups Q; Q is selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN, SO2CH3 or a group -O[(CR1R2]pQ1; or Q may be a group Q2; Q1 is phenyl, which may be optionally substituted with n substituents selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN, or a group Q2; or corresponds to 2,2-difluoro- benzo[d][1,3]dioxol-4-yl; Q2 is a 5- or 6-membered heteroaryl containing at least one nitrogen atom, which may optionally substituted with n substituents selected from a group consisting of: C1 C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; P is a 6-membered heteroaryl or a 8-1 1 membered bicylic heteroaryl group, which may be substituted with n substituents selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; R1 is hydrogen or C1-C3 alkyl; R2 is hydrogen or C1-C3 alkyl; n is 1, 2 or 3; p is 0, 1 or 2; and with the proviso that when R corresponds to phenyl, P is substituted by at least one CF3; processes for the preparation of those compounds, pharmaceutical compositions containing one or more compounds of formula (I) and their use as dual antagonists of the Orexin 1 and Orexin 2 receptors.

FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS

Disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo [3.2.0]heptane compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.