1203493-90-6

Basic information

• Product Name: 1-phenyl-3-(thiophen-2-yl)butan-1-one
• Synonyms: 1-phenyl-3-(thiophen-2-yl)butan-1-one
• CAS NO: 1203493-90-6
• Molecular Weight: 230.331
• Mol File: 1203493-90-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-phenyl-3-(thiophen-2-yl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(thiophen-2-yl)butan-1-one(1203493-90-6)
• EPA Substance Registry System: 1-phenyl-3-(thiophen-2-yl)butan-1-one(1203493-90-6)

Safety Data

• Hazardous Substances Data: 1203493-90-6(Hazardous Substances Data)

Upstream product

• 2206-94-2 1-acetoxy-1-phenylethene 
• 115510-91-3 1-(thien-2-yl)ethanol 
• 30616-73-0 2-isopropenylthiophene 
• 5440-69-7 N-isopropylbenzamide 
• 879-85-6 (E/Z)-ethyl 3-(thiophen-2-yl)but-2-enoate 
• 88-15-3 2-Acetylthiophene 

Relevant articles and documents

Tf2O/TTBP (2,4,6-Tri-tert-butylpyrimidine): An Alternative Amide Activation System for the Direct Transformations of Both Tertiary and Secondary Amides

Ten types of Tf2O/TTBP-mediated amide transformation reactions were investigated. The results showed that compared with pyridine derivatives 2,6-di-tert-butyl-4-methylpyridine (DTBMP) and 2-fluoropyridine (2-F-Pyr.), TTBP can serve as an alternative amide activation system for the direct transformation of both secondary and tertiary amides. For most surveyed examples, higher or comparable yields were generally obtained. In addition, Tf2O/TTBP combination was used to promote the condensation reactions of 2-(tert-butyldimethylsilyloxy)furan (TBSOF) with both tertiary and secondary amides, the one-pot reductive Bischler-Napieralski-type reaction of tertiary lactams, and Movassaghi and Hill's modern version of the Bischler-Napieralski reaction. The value of the Tf2O/TTBP-based methodology was further demonstrated by the concise and high-yielding syntheses of several natural products.

Ketone Synthesis by Direct, Orthogonal Chemoselective Hydroacylation of Alkenes with Amides: Use of Alkenes as Surrogates of Alkyl Carbanions

Direct functionalization of alkenes and direct transformation of carboxamides are two exciting areas that have attracted considerable attention in recent years. We report herein that secondary amides, the least reactive derivatives of carbonyl compounds, upon activated with triflic anhydride, can serve as effective hydroacylating reagents in partner with alkenes to yield ketones at ambient temperature. The method was applied to the one-step synthesis of racemic dihydro-ar-turmerone. In this method, alkenes serve as surrogates of organometallic reagents, which allows the orthogonal chemoselective reactions. The ready availability of many olefins such as camphene and norbornene permits one-step ketone synthesis that would require several steps by conventional methods.