1203563-67-0

Basic information

• Product Name: (1R,2S)-2-(((1,3-dioxolan-2-yl)methyl)(methyl)amino)-1-phenylpropan-1-ol
• Synonyms: (1R,2S)-2-(((1,3-dioxolan-2-yl)methyl)(methyl)amino)-1-phenylpropan-1-ol
• CAS NO: 1203563-67-0
• Molecular Weight: 251.326
• Mol File: 1203563-67-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,2S)-2-(((1,3-dioxolan-2-yl)methyl)(methyl)amino)-1-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-2-(((1,3-dioxolan-2-yl)methyl)(methyl)amino)-1-phenylpropan-1-ol(1203563-67-0)
• EPA Substance Registry System: (1R,2S)-2-(((1,3-dioxolan-2-yl)methyl)(methyl)amino)-1-phenylpropan-1-ol(1203563-67-0)

Safety Data

• Hazardous Substances Data: 1203563-67-0(Hazardous Substances Data)

Upstream product

• 4360-63-8 2-bromomethyl-1,3-dioxolane 
• 299-42-3 ephedrine 

Relevant articles and documents

Asymmetric Sulfinylations of N-Methylephedrine-Modified Tri- or Tetraalkyl Zincates by Symmetric Diaryl Sulfoxides

Diethylzinc was treated with 1 or 2 equiv. of AlkMgCl or PhMgBr (preferably) or with 1 equiv. of nBuLi (less efficiently) for forming species – plausibly zincates – which were sulfinylated by diaryl sulfoxides to give racemic alkyl aryl sulfoxides in yields reaching 100 %. Dialkylzinc reagents were also activated by treatments with 1 or 2 equiv. of an enantiomerically pure alkylmagnesium β-aminoalkoxide. This worked best when the alkoxide stemmed from a dialkylmagnesium reagent and an equimolar amount of N-methyl-(–)-ephedrine. This second activation mode allowed sulfinylations of what was originally the dialkylzinc reagent with diaryl sulfoxides. This generated alkyl aryl sulfoxides with enantiomeric ratios up to 93:7 in up to 100 % yield.