1203669-89-9Relevant articles and documents
Rapid solid-phase syntheses of a peptidic-aminoglycoside library
Kukielski, Casey,Maiti, Krishnagopal,Bhaduri, Sayantan,Story, Sandra,Arya, Dev P.
, p. 4418 - 4428 (2018)
A library of mono- and di-amino acid peptidic-aminoglycosides (PAs), with kanamycin and neomycin as the model aminoglycosides, was systematically and rapidly synthesized via solid phase peptide synthesis. Aminoglycosides were first converted into N-Boc pr
GUANIDINYLATED AMINOGLYCOSIDE-LIPID CONJUGATES
-
Paragraph 0097, (2013/03/26)
Guanadinylated aminoglycoside-lipid conjugates are prepared. Such conjugates may comprise an aminoglycoside such as an aminoglyucoside antibiotic like neomycin or kanamycin, at least one guanidino group attached to a primary or secondary carbon atom of the aminoglyucoside group and at least one lipid group attached through a bond or a linker to a branched carbon atom of the aminoglycoside. These conjugates exhibit improve antibacterial activity and may be used in conjunction with another antibiotic.