120378-89-4

Basic information

• Product Name: (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid ethyl ester
• Synonyms: (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid ethyl ester
• CAS NO: 120378-89-4
• Molecular Weight: 266.337
• Mol File: 120378-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid ethyl ester(120378-89-4)
• EPA Substance Registry System: (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid ethyl ester(120378-89-4)

Safety Data

• Hazardous Substances Data: 120378-89-4(Hazardous Substances Data)

Upstream product

• 148041-28-5 (3R,4S)-5-Benzyloxy-4-methyl-3-trimethylsilanyloxy-pentanoic acid ethyl ester 
• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 
• 79027-28-4 (2S)-3-(benzyloxy)-2-methylpropanal 

Downstream Products

• 120442-92-4 (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-methoxy-azetidin-2-one 
• 120378-87-2 (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-(1-hydroxy-ethyl)-1-methoxy-azetidin-2-one 
• 120378-96-3 (S)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methoxy-azetidin-2-one 
• 122620-48-8 (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-methoxy-azetidin-2-one 
• 93711-85-4 (2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid 
• 121534-58-5 (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid methoxy-amide 

Relevant articles and documents

A New Synthetic Route to the Key Precursor of 1β-Methylcarbapenem Antibiotics from (S)-Methyl 3-Hydroxy-2-methylpropanoate

A new synthetic route to the 1β-methylcarbapenem precursor from (S)-methyl 3-hydroxy-2-methylpropanoate has been developed which involves as a key step the chelation-controlled aldol reaction of (S)-3-benzyloxy-2-methylpropanal with ketene trimethylsilyl acetal of ethyl (trimethylsilyl)acetate.