1203852-78-1

Basic information

• Product Name: 1-(2-(methoxycarbonyl)-4-nitrophenyl)-2-bromo-5-methyl-1H-imidazole-4-carboxylic ethyl ester
• CAS NO: 1203852-78-1
• Molecular Weight: 412.197
• Mol File: 1203852-78-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-(methoxycarbonyl)-4-nitrophenyl)-2-bromo-5-methyl-1H-imidazole-4-carboxylic ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(methoxycarbonyl)-4-nitrophenyl)-2-bromo-5-methyl-1H-imidazole-4-carboxylic ethyl ester(1203852-78-1)
• EPA Substance Registry System: 1-(2-(methoxycarbonyl)-4-nitrophenyl)-2-bromo-5-methyl-1H-imidazole-4-carboxylic ethyl ester(1203852-78-1)

Safety Data

• Hazardous Substances Data: 1203852-78-1(Hazardous Substances Data)

Upstream product

• 1203852-75-8 1-(2-(methoxycarbonyl)-4-nitrophenyl)-5-methyl-1H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

A concise and efficient synthesis of flumazenil and its precursor for radiolabeling with fluorine-18

Presently there is a strong interest in developing radioligands for in vivo imaging the GABAA-Bz site with positron emission tomography (PET). Flumazenil (1), a high-affinity GABAA-Bz site inverse agonist, is amenable for 11C and 18F-labeling. The current methods for synthesis of 1 and its precursor for 18F-labeling are not ideal and restrict structure-activity relationship (SAR) development. Herein we present a novel and less troublesome synthesis of 1 and its cognates to aid in the development of improved radioligands for PET imaging of GABAA-Bz site.