1204-21-3

Basic information

• Product Name: 2-BROMO-2',5'-DIMETHOXYACETOPHENONE
• Synonyms: 2-BROMO-2',5'-DIMETHOXYACETOPHENONE;2-BROMO-1-(2,5-DIMETHOXYPHENYL)ETHANONE;bromomethyl 2,5-dimethoxyphenyl ketone;2-BROMO-2'',5''-DIMETHOXYACETOPHENONE 98%;2,5-dimethoxyphenacyl bromide ,2-bromo1-(2,5-dimethoxyphenyl)ethanone;1,4-Dimethoxy-2-(bromoacetyl)benzene;α-Bromo-2',5'-dimethoxyacetophenone;ω-Bromo-2',5'-dimethoxyacetophenone
• CAS NO: 1204-21-3
• Molecular Formula: C₁₀H₁₁BrO₃
• Molecular Weight: 259.1
• EINECS: 214-873-2
• Product Categories: C10;Carbonyl Compounds;Ketones;Acetophenone series
• Mol File: 1204-21-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 83-85 °C(lit.)
• Boiling Point: 323.076 °C at 760 mmHg
• Flash Point: 149.191 °C
• Appearance: beige fine cryst. powder or fine cryst. needles
• Density: 1.5471 (rough estimate)
• Refractive Index: 1.4620 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-2',5'-DIMETHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-2',5'-DIMETHOXYACETOPHENONE(1204-21-3)
• EPA Substance Registry System: 2-BROMO-2',5'-DIMETHOXYACETOPHENONE(1204-21-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-27-37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 1204-21-3(Hazardous Substances Data)

Usage

Description

2-Bromo-2',5'-dimethoXYacetophenone is an organic compound characterized by its beige fine crystalline powder or fine crystalline needles. It is known for its ability to be used in composing phase change inks, which are inks that change phase in response to temperature variations.

Uses

Used in Printing Industry:
2-Bromo-2',5'-dimethoXYacetophenone is used as a component in phase change inks for its ability to alter its phase in response to temperature changes. This property allows for the creation of inks that can be easily manipulated and applied to various surfaces, making it a valuable asset in the printing industry.
Used in Manufacturing of Phase Change Materials:
In addition to its application in inks, 2-Bromo-2',5'-dimethoXYacetophenone can also be utilized in the development and production of phase change materials. These materials are essential in various industries, such as electronics and construction, where temperature regulation and energy efficiency are crucial. The compound's unique properties make it a suitable candidate for creating materials that can effectively manage heat and maintain desired temperatures.

Preparation

Obtained by bromination of 2,5-dimethoxyacetophenone using polymersupported pyridinium bromide perbromide in chloroform at r.t.

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 150-78-7 1,4-dimethoxybezene 
• 598-21-0 2-Bromoacetyl bromide 
• 1201-38-3 2',5'-dimethoxyacetophenone 

Downstream Products

• 76949-68-3 2-(2,5-dimethoxy-phenyl)-indolizine 
• 851531-99-2 2-bromo-1-(2,5-dimethoxy-4-nitrophenyl)ethan-1-one 
• 99057-95-1 2-bromo-1-(3,6-dimethoxy-2-nitrophenyl)ethan-1-one 
• 100884-75-1 (2,5-dimethoxy-phenacyl)-methyl-malonic acid 
• 55931-01-6 (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-hept-5-enoic acid 2-(2,5-dimethoxy-phenyl)-2-oxo-ethyl ester 
• 55987-38-7 (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-cyclopentyl]-hept-5-enoic acid 2-(2,5-dimethoxy-phenyl)-2-oxo-ethyl ester 
• 55931-03-8 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-cyclopentyl]-heptanoic acid 2-(2,5-dimethoxy-phenyl)-2-oxo-ethyl ester 
• 55931-02-7 (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((1E,5Z)-(S)-3-hydroxy-octa-1,5-dienyl)-5-oxo-cyclopentyl]-hept-5-enoic acid 2-(2,5-dimethoxy-phenyl)-2-oxo-ethyl ester 
• 55931-04-9 (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,5Z)-(S)-3-hydroxy-octa-1,5-dienyl)-cyclopentyl]-hept-5-enoic acid 2-(2,5-dimethoxy-phenyl)-2-oxo-ethyl ester 
• 42574-11-8 Dithiocarbonic acid S-[2-(2,5-dimethoxy-phenyl)-2-oxo-ethyl] ester O-isopropyl ester 
• 143696-73-5 2-(2,5-Dimethoxy-phenyl)-imidazo[1,2-a]pyrimidine 
• 143951-27-3 2,3-dimethyl-6-(2,5-dimethoxyphenyl)imidazo<2,1-b>thiazole 
• 1201-38-3 2',5'-dimethoxyacetophenone 

Relevant articles and documents

Intramolecular weak hydrogen bonds in substituted 4-arylthiazoles

We have synthesized new polysubstituted 4-arylthiazoles with a substitution pattern able to form intramolecular weak hydrogen bonds as secondary structure, and besides, displaying in the aromatic region of their 1H-NMR spectra an ABX spin system and only one singlet (the thiazolic proton), thus permitting us to make doubtless assignments. These results confirmed previous assignments made by us in other thiazole-derivatives prepared by the first time. The spectroscopic data (IR, 1H-NMR and MS) of these thiazoles, as well as of the required intermediates, are discussed.

Mutant type IDH inhibitors, preparation method thereof, and pharmaceutical composition containg the same as an active ingredient

The present invention is a mutated IDH1 inhibitor. The present invention relates to a compound represented by chemical formula 1, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof according to the present invention, which has excellent inhibitory activity against mutated IDH1 and can reduce intracellular tumor-induced metabolite (2-HG), and a health functional food composition for preventing or IDH1 treating cancer, comprising the same as an active ingredient.

Nucleus-independent chemical shift (NICS) as a criterion for the design of new antifungal benzofuranones

The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (p –1 for Candida glabrata, Candida krusei and Candida guilliermondii with compounds 15-32, 15-15 and 15-1. The MIC for filamentous fungi was 1.95 μg·mL–1 for Aspergillus niger for compounds 15-1, 15-33 and 15-34. The results obtained support the use of NICS in the molecular design of compounds with antifungal activity.

One-Pot Preparation of Aromatic Amides, 4-Arylthiazoles, and 4-Arylimidazoles from Arenes

Simple treatment of arenes with α-bromoacetyl chloride and AlCl3, followed by the reaction with molecular iodine and aq. NH3, thioamides, or amidines gave the corresponding primary aromatic amides, 4-arylthiazoles, or 4-arylimidazoles in good yields, respectively. Aryl α-bromomethyl ketones are the key intermediates in those reactions. Primary aromatic amides were formed from arenes through the reaction of aryl α-bromomethyl ketones with molecular iodine and aq. NH3, and 4-arylthiazoles and 4-arylimidazoles were formed from arenes through the reactions of aryl α-bromomethyl ketones with thioamides and amidines, respectively, in one pot under transition-metal-free conditions.