1204232-46-1

Basic information

• Product Name: 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol methanesulfonate salt
• Synonyms: 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol methanesulfonate salt
• CAS NO: 1204232-46-1
• Molecular Weight: 345.46
• Mol File: 1204232-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol methanesulfonate salt(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol methanesulfonate salt(1204232-46-1)
• EPA Substance Registry System: 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol methanesulfonate salt(1204232-46-1)

Safety Data

• Hazardous Substances Data: 1204232-46-1(Hazardous Substances Data)

Upstream product

• 75-75-2 methanesulfonic acid 
• 93413-76-4 1-[cyano(4-methoxyphenyl)methyl]cyclohexanol 

Downstream Products

• 93413-77-5 N,N-didesmethylvenlafaxine 

Relevant articles and documents

A PROCESS FOR PREPARATION OF PHENETHYLAMINE DERIVATIVE

The present invention relates to a process for the preparation of 1-[2-amino-1-(4-substituted phenyl)ethyl]cyclohexanol (3) (where R is OMe, OH), said process comprising the steps of; subjecting a reaction mixture of substituted phenylacetonitrile (2) in alcohol, an organic acid, and a hydrogenating catalyst in the presence of hydrogen gas pressure in the range of 0.5 kg/cm2 to 30 kg/cm2 and temperature in the range of 0-100°C; filtering and concentrating the cooled reaction mixture to obtain an acid addition salt of 1-[2-amino-1-(4-substituted phenyl)ethyl]cyclohexanol (4); and treating the acid addition salt of 1-[2-amino-1-(4-substituted phenyl)ethyl]cyclohexanol (4) with an ester in presence of a base to obtain 1-[2-amino-1-(4-substituted phenyl) ethyl] cyclohexanol (3).