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120427-95-4

120427-95-4

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  • 4-(2'-Bromoethyl)-3-Chloro-1, 3-Dihydro-2-Indoline-2-One

    Cas No: 120427-95-4

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120427-95-4 Usage

Chemical Properties

Light brown or off -white power

Check Digit Verification of cas no

The CAS Registry Mumber 120427-95-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,4,2 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120427-95:
(8*1)+(7*2)+(6*0)+(5*4)+(4*2)+(3*7)+(2*9)+(1*5)=94
94 % 10 = 4
So 120427-95-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H9BrClNO/c11-5-4-6-2-1-3-7-8(6)9(12)10(14)13-7/h1-3,9H,4-5H2,(H,13,14)

120427-95-4Relevant articles and documents

Preparation method of 4-(2-bromoethyl)-1, 3-dihydro-2H-indole-2-ketone

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Paragraph 0032; 0035; 0036; 0040; 0043-0044; 0048; 0051-0052, (2021/05/05)

The invention provides a preparation method of 4-(2-bromoethyl)-1, 3-dihydro-2H-indole-2-ketone, and the preparation method of the 4-(2-bromoethyl)-1, 3-dihydro-2H-indole-2-ketone is characterized in that the 4-(2-bromoethyl)-1, 3-dihydro-2H-indole-2-ketone is prepared by taking o-bromoethyl benzaldehyde as an initial raw material and carrying out a series of reactions. The raw materials are cheap and easy to obtain, the product yield and purity are high, and the method has excellent economic and environment-friendly benefits.

Development of large-scale syntheses of ropinirole in the pursuit of a manufacturing process

Hayler, John D.,Howie, Simon L. B.,Giles, Robert G.,Negus, Alan,Oxley, Paul W.,Walsgrove, Timothy C.,Whiter

, p. 3 - 9 (2013/09/08)

Two plant syntheses of ropinirole {4-[2-(di-n-propyIamino)-ethyl]-1,3-dihydro-2H-indolin-2-one hydrochloride, SK&F-101468-A} using the ferric chloride mediated cyclisation of β-nitrostyrenes to form 3-chlorooxindoles as the key step are described. The first synthesis suffered the severe limitation of the final-step chemistry being nonselective in the reaction between di-n-propylamine and the bromide precursor to ropinirole as both substitution and elimination pathways were promoted and by-product formation at a level of 40% resulted. This problem was rectified in the latter synthesis by the more selective reaction between di-n-propylamine and the sulfonate ester precursor promoting ropinirole formation to a level of 88%. This second synthesis is now used as the commercial route, and problems (and their solutions) identified during the development of this route are now described. The identification of novel by-products which enabled the Sommelet oxidation step to be optimised is also reported. A unimolecular decomposition mechanism during hydrolysis of the hexaminium salt to form the key benzaldehyde intermediate is proposed and substantiated with experimental data.

Process for preparing substituted isoindolinone derivatives

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, (2008/06/13)

This invention relates to an improved process for the preparation of substituted indolinone derivatives using reductive cyclization conditions.

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