120445-33-2

Basic information

• Product Name: o-nitrobenzaldehyde semicarbazone
• CAS NO: 120445-33-2
• Molecular Weight: 208.177
• Mol File: 120445-33-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: o-nitrobenzaldehyde semicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: o-nitrobenzaldehyde semicarbazone(120445-33-2)
• EPA Substance Registry System: o-nitrobenzaldehyde semicarbazone(120445-33-2)

Safety Data

• Hazardous Substances Data: 120445-33-2(Hazardous Substances Data)

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 4426-72-6 hydrazine carboxamide 
• 563-41-7 semicarbazide hydrochloride 
• 1929-19-7 bis-(2-nitro-benzylidene)-hydrazine 
• 127-08-2 potassium acetate 

Downstream Products

• 109060-71-1 2-amino-5-(2'-nitrophenyl)-1,3,4-oxadiazole 
• 23102-23-0 3-(2-nitrophenyl)-4H-1,2,4-triazol-5-ol 
• 552-89-6 2-nitro-benzaldehyde 
• 553-74-2 nitrin 
• 610-64-0 1-(2-nitrobenzylidene)-2-phenylhydrazine 

Relevant articles and documents

A rapid derivatization method for analyzing nitrofuran metabolites in fish using ultra-performance liquid chromatography-tandem mass spectrometry

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Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide

A series of N-(substituted benzothiazole-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compoundN-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABAA receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property.

Semicarbazone derivatives as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation

A series of hydrazinecarboxamide derivatives were synthesized and examined against urease for their inhibitory activity. Among the series, the 1-(3-fluorobenzylidene)semicarbazide (4a) (IC50 = 0.52 ± 0.45 μM), 4u (IC50 = 1.23 ± 0.32 μM) and 4h (IC50 = 2.22 ± 0.32 μM) were found most potent. Furthermore, the molecular docking study was also performed to demonstrate the binding mode of the active hydrazinecarboxamide with the enzyme, urease. In order to estimate drug likeness of compounds, in silico ADME evaluation was carried out. All compounds exhibited favorable ADME profiles with good predicted oral bioavailability.