120445-90-1

Basic information

• Product Name: (m-methylphenyl)ethanone semicarbazone
• Synonyms: (m-methylphenyl)ethanone semicarbazone
• CAS NO: 120445-90-1
• Molecular Weight: 191.233
• Mol File: 120445-90-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (m-methylphenyl)ethanone semicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: (m-methylphenyl)ethanone semicarbazone(120445-90-1)
• EPA Substance Registry System: (m-methylphenyl)ethanone semicarbazone(120445-90-1)

Safety Data

• Hazardous Substances Data: 120445-90-1(Hazardous Substances Data)

Upstream product

• 563-41-7 semicarbazide hydrochloride 
• 585-74-0 3-Methylacetophenone 

Downstream Products

• 879996-85-7 C₁₇H₂₆N₂O₂Si₂ 
• 879996-72-2 3-m-tolyl-1H-pyrazole-4-carboxylic acid 
• 879996-61-9 3-m-tolyl-1H-pyrazole-4-carbaldehyde 
• 620-14-4 1-Methyl-3-ethylbenzene 

Relevant articles and documents

New approach towards the synthesis of selenosemicarbazones, useful compounds for Chagas' disease

Herein, we describe a new approach towards the synthesis of selenosemicarbazones. The reaction involves an O-Se exchange of semicarbazones using Ishihara reagent. Eleven selenosemicarbazones were prepared using this methodology, with low to moderate yields. Among the prepared compounds the m-bromo phenyl methyl derivative 1b was selected to be evaluated in vivo, in a murine model of acute Chagas' disease. Compound 1b 10 mg/kg bw/day reduced 50% of parasitaemia profile compared with the control group, but was less effective than Benznidazole (50 mg/kg bw/day reduced 90%) and toxic. These studies are important to guide future Chagas drug design.