120452-49-5

Basic information

• Product Name: Carbamic acid, [2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (R)-
• CAS NO: 120452-49-5
• Molecular Formula: C19H22N2O4
• Molecular Weight: 342.395
• Mol File: 120452-49-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (R)-(120452-49-5)
• EPA Substance Registry System: Carbamic acid, [2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (R)-(120452-49-5)

Safety Data

• Hazardous Substances Data: 120452-49-5(Hazardous Substances Data)

Upstream product

• 2448-45-5 Cbz-D-Phe 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 41518-17-6 C₂₂H₂₅NO₆ 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 120452-50-8 (R)-N-Cbz-2-amino-1-phenyl-3-butanone 
• 120452-67-7 (2R,3R)-N-Boc-2-amino-3-azido-1-phenylpentane 
• 120452-69-9 (2R,3S)-N-Boc-2-amino-3-azido-1-phenylpentane 
• 120452-61-1 (4R,5R)-4-benzyl-3-Boc-5-ethyloxazolidin-2-one 
• 120452-59-7 (4R,5S)-4-benzyl-3-Boc-5-ethyloxazolidin-2-one 
• 120452-66-6 (2R,3R)-N-Boc-2-amino-3-azido-1-phenylbutane 
• 120452-68-8 (2R,3S)-N-Boc-2-amino-3-azido-1-phenylbutane 
• 120452-60-0 (4R,5R)-4-benzyl-3-Boc-5-methyloxazolidin-2-one 
• 120452-58-6 (4R,5S)-4-benzyl-3-Boc-5-methyloxazolidin-2-one 
• 120452-63-3 (2R,3S)-N-Boc-2-amino-3-hydroxy-1-phenylpentane 
• 120452-65-5 (2R,3R)-N-Boc-2-amino-3-hydroxy-1-phenylpentane 
• 120452-64-4 (2R,3R)-N-Boc-2-amino-3-hydroxy-1-phenylbutane 
• 120452-62-2 (2R,3S)-N-Boc-2-amino-3-hydroxy-1-phenylbutane 
• 120452-57-5 (4R,5R)-4-benzyl-5-ethyloxazolidin-2-one 

Relevant articles and documents

NOVEL COMPOUNDS

The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the description and claims. T

Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors

Re-examination of the design of the cyclic urea class of HIV protease (HIVPR) inhibitors suggests a general approach to designing novel nonpeptide cyclic HIVPR inhibitors. This process involves the inversion of the stereochemical centers of the core transition-state isostere of the linear HIVPR inhibitors and cyclization of the resulting core using an appropriate cyclizing reagent. As an example, this process is applied to the diamino alcohol class of HIVPR inhibitors to give tetrahydropyrimidinones. Conformational analysis of the tetrahydropyrimidinones and modeling of its interaction with the active site of HIVPR suggested modifications which led to very potent inhibitors of HIVPR (24 with a K(i) = 0.018 nM). The X-ray crystallographic structure of the complex of 24 with HIVPR confirms the analysis and modeling predictions. The example reported in this study and other examples that are cited indicate that this process may be generally applicable to other linear inhibitors.

An efficient and enantioselective synthesis of a chiral primary amine

An efficient and enantioselective method for the preparation of a chiral primary amine has been developed. Starting from N-protected L or D-amino acid the sequence involves coupling with N-methoxy-N-methylamine, acylation, olefination with potassium bis(trimethylsilyl)amide, and hydrogenation.