1204593-75-8Relevant articles and documents
(S)-α-methyl,α-amino acids: A new stereocontrolled synthesis
Balducci, Daniele,Lazzari, Ilaria,Monari, Magda,Piccinelli, Fabio,Porzi, Gianni
experimental part, p. 829 - 837 (2010/09/04)
A new and convenient stereocontrolled synthesis of the optically pure (S)-α-methyl,α-amino acids 6(a-d) that exploits the chiral synthon 1,4-N,N-[(S)-1-phenylethyl]-piperazine-2,5-dione (1) is described. The (S)-1-phenylethyl group, bonded to each of the N-atoms of the 2,5-diketopiperazine, acts as a chiral inductor in the first alkylation, while the steric hindrance appears to be the determining factor of stereocontrol in third and forth alkylation.