120547-24-2

Basic information

• Product Name: N-(4-methylphenyl)-N-methylglycine ethyl ester
• Synonyms: N-(4-methylphenyl)-N-methylglycine ethyl ester
• CAS NO: 120547-24-2
• Molecular Weight: 207.272
• Mol File: 120547-24-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(4-methylphenyl)-N-methylglycine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)-N-methylglycine ethyl ester(120547-24-2)
• EPA Substance Registry System: N-(4-methylphenyl)-N-methylglycine ethyl ester(120547-24-2)

Safety Data

• Hazardous Substances Data: 120547-24-2(Hazardous Substances Data)

Upstream product

• 623-08-5 N-methyl-p-toluidine 
• 109-92-2 ethyl vinyl ether 
• 623-73-4 diazoacetic acid ethyl ester 
• 99-97-8 Dimethyl-p-toluidine 
• 105-36-2 ethyl bromoacetate 
• 924-44-7 glyoxylic acid ethyl ester 

Downstream Products

• 2842-44-6 2-(methyl(p-tolyl)amino)ethan-1-ol 
• 120547-26-4 endo-7-(p-tolylmethylamino)bicyclo<3.2.0>hept-2-en-6-one 
• 120662-12-6 exo-7-(p-tolylmethylamino)bicyclo<3.2.0>hept-2-en-6-one 
• 120547-28-6 endo-10-(p-tolylmethylamino)bicyclo<6.2.0>decan-9-one 
• 120547-30-0 endo-9-(p-tolylmethylamino)bicyclo<5.2.0>nonane 
• 120547-25-3 N-p-tolyl-N-methylglycine hydrochloride 

Relevant articles and documents

Photoredox-Catalyzed α-Aminomethyl Carboxylation of Styrenes with Sodium Glycinates: Synthesis of γ-Amino Acids and γ-Lactams

A visible-light photoredox-catalyzed reductive α-aminomethyl carboxylation of styrenes with sodium glycinates and CO2 has been developed to synthesize a series of α,α-disubstituted γ-amino acids and γ-lactams with high efficiency and regioselectivity. Notably, CO2 released from the decarboxylation step can be reused for the subsequent carboxylation. Distinct from the previous reactions with the same type of substrates leading to simple decarboxylation and olefin hydroalkylation, this process involves additional CO2 sequestration, thus leading to olefin α-aminomethyl carboxylation. These findings not only provide new access to α,α-disubstituted γ-amino acids and γ-lactams but also serve as a proof of concept for CO2 reutilization in decarboxylation reactions.

Access to α-Amino Acid Esters through Palladium-Catalyzed Oxidative Amination of Vinyl Ethers with Hydrogen Peroxide as the Oxidant and Oxygen Source

A novel and convenient palladium catalytic system for the synthesis of α-amino acid esters from simple starting materials is reported. Hydrogen peroxide not only acts as the green oxidant, but also as the oxygen source. This strategy for the conversion of amines and vinyl ethers into highly functionalized and structurally diverse α-amino acid esters is characterized by the simplicity of the experimental procedure, mild reaction conditions, high atom economy, scalability, and practicability.

Iron-catalyzed synthesis of glycine derivatives via carbon-nitrogen bond cleavage using diazoacetate

Treatment of tertiary amines with diazoacetate in the presence of a catalytic amount of an iron salt, FeCl3, in ethanol gave glycine derivatives. In this reaction, a carbon-nitrogen single bond of the amine was cleaved. The Royal Society of Chemistry 2010.