120600-74-0Relevant articles and documents
Process for preparing 6-/D(-)-Alpha-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-phenylacetamido/pennicillanic acid
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, (2008/06/13)
Disclosed is a process for preparing 6-[D(-)-alpha-(4-ethyl-2,3-dioxo--1-piperazinecarboxamido)-phenylacetamido] penicillanic acid as well as pharmaceutically acceptable alkali metal salts thereof of the formula (I) wherein A represents a hydrogen atom, a sodium atom or a potassium atom, wherein active thioesters of 4-ethyl-2,3-dioxo-1-piperazinecarboxylic acid of the formula (II) wherein R represents a 2-mercaptobenzimidazole radical, 2-mercaptobenzoxa-zole radical and preferably 2-mercaptobenzothiazole radical, is condensed with silylated form of 6-[D(-)-alpha-aminophenylacetatamido] penicillanic acid of the formula (III) The compound of the formula II is a novel compound.