1206972-45-3

Basic information

• Product Name: 2-Chloro-5-(trifluoroMethoxy)pyridine
• Synonyms: 2-Chloro-5-(trifluoroMethoxy)pyridine;2-Chloro-5-(trifluoromethoxy)
• CAS NO: 1206972-45-3
• Molecular Formula: C₆H₃ClF₃NO
• Molecular Weight: 197.5423296
• Mol File: 1206972-45-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 41-43 °C(Press: 15 Torr)
• Appearance: /
• Density: 1.463±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.55±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-5-(trifluoroMethoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-(trifluoroMethoxy)pyridine(1206972-45-3)
• EPA Substance Registry System: 2-Chloro-5-(trifluoroMethoxy)pyridine(1206972-45-3)

Safety Data

• Hazardous Substances Data: 1206972-45-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-(trifluoromethoxy)pyridine is a specialized chemical compound. It belongs to the class of organic compounds known as aryl chlorides, specifically, it is a pyridine compound, with the aryl portion being the 2-chloro-5-trifluoromethoxy pyridine part. The presence of the trifluoromethoxy group suggests that it is a fluorinated compound, which often have unique properties and uses in various applications, such as pharmaceuticals and agrochemicals. As a compound, it is expected to appear as a clear, colorless liquid or solid, although specific properties could vary based on purity and other factors. Its safe handling and storage require appropriate measures due to its reactivity and potential hazards that typical chloro-organic and fluoro-organic compounds possess.

Upstream product

• 41288-96-4 6-chloropyridine-3-ol 
• 1258190-69-0 S-methyl 2-chloropyridine-5-dithiocarbamate 
• 1221171-73-8 2-chloro-5-(trichloromethoxy)pyridine 

Downstream Products

• 1221171-77-2 2-chloro-5-(trifluoromethoxy)isonicotinic acid 
• 888327-36-4 2-bromo-5-(trifluoromethoxy)pyridine 
• 1361693-01-7 3-bromo-5-(trifluoromethoxy)pyridin-2-amine 

Relevant articles and documents

Sequential Xanthalation and O-Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers

Molecules containing trifluoromethoxyaryl groups are of interest in pharmaceutical, agrochemical, and materials science research, due to their unique physical and electronic properties. Many of the known methods to synthesize aryl trifluoromethyl ethers require harsh reagents and highly controlled reaction conditions and rarely occur when heteroaromatic units are present. The two-step O-trifluoromethylation of phenols via aryl xanthates is one such method that suffers from these drawbacks. Herein, we report a method for the synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salts and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.