1206979-33-0

Basic information

• Product Name: 6-Chloro-1H-pyrazolo[4,3-c]pyridine
• Synonyms: 6-Chloro-1H-pyrazolo[4,3-c]pyridine;1H-Pyrazolo[4,3-c]pyridine, 6-chloro-;6-Chloro-5-azaindazole;6-chloro-pyrazolo[4,3-c]pyridine;6-Chloro-1H-Pyrazolo[4,3-C]Pyridine(WXC01805)
• CAS NO: 1206979-33-0
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.56906
• Mol File: 1206979-33-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 358℃
• Flash Point: 201℃
• Appearance: /
• Density: 1.531
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.46±0.40(Predicted)
• CAS DataBase Reference: 6-Chloro-1H-pyrazolo[4,3-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-1H-pyrazolo[4,3-c]pyridine(1206979-33-0)
• EPA Substance Registry System: 6-Chloro-1H-pyrazolo[4,3-c]pyridine(1206979-33-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 1206979-33-0(Hazardous Substances Data)

Usage

General Description

6-Chloro-1H-pyrazolo[4,3-c]pyridine, also known by its chemical formula C8H5ClN4, is a heterocyclic compound belonging to the class of pyrazole derivatives. It is a chlorinated pyridine with a pyrazole ring fused to it, and it is commonly used in the synthesis of pharmaceutical drugs and biologically active compounds. This chemical is a potential drug candidate due to its ability to modulate the activities of certain enzymes and receptors in the human body. Its unique structure and properties make it a valuable building block for medicinal chemistry research and development. Additionally, its chlorinated nature also gives it potential use as a precursor in the production of other fine chemicals.

Upstream product

• 40296-46-6 ethyl 4,6-dichloronicotinate 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 
• 79398-27-9 methyl 4,6-dihydroxypyridine-3-carboxylate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 65973-52-6 methyl 4,6-dichloropyridine-3-carboxylate 
• 73998-95-5 2,4-dichloro-5-hydroxymethylpyridine 
• 871836-50-9 1H-pyrazolo[4,3-c]pyridine N-oxide 
• 1060811-62-2 2,4-dichloro-5-pyridinecarboxaldehyde 

Downstream Products

• 1431720-68-1 6-chloro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 

Relevant articles and documents

COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS

The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE

The invention provides tetrahydronaphthyridine and related compounds, pharmaceutical compositions, methods of inhibiting RORγ activity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders using such tetrahydronaphthyridine and related compounds.

NITROGENOUS FUSED BICYCLIC COMPOUND

A novel nitrogenous fused bicyclic compound represented by the following general formula [1] or a pharmacologically acceptable salt of the compound. They have excellent SK channel blocking activity and are useful as a medicine. [I] (In the formula, R 0 represents hydrogen, halogeno, etc.; R 1 represents a group represented by the formula (a) or (b); A represents a group represented by the formula (X) or (Y); D 1 , D 2 and D 3 each represents N or CH; R 2 represents halogeno or optionally halogenated lower alkyl, etc.; R 3 represents hydrogen or lower alkyl; and Q represents lower alkylene.)