120728-10-1 Usage
Description
N-Boc-1-aminocyclobutanecarboxylic acid, also known as Boc-1-aminocyclobutane-1-carboxylic Acid, is an organic compound with the molecular formula C9H15NO4. It is a derivative of cyclobutanecarboxylic acid, featuring a Boc-protected amino group, which is crucial for its reactivity and stability in various chemical reactions. N-Boc-1-aminocyclobutanecarboxylic acid is a valuable building block in the synthesis of various pharmaceuticals and bioactive molecules due to its unique structure and functional groups.
Uses
Used in Pharmaceutical Synthesis:
N-Boc-1-aminocyclobutanecarboxylic acid is used as a key intermediate in the synthesis of dipeptidyl nitriles with cathepsin-inhibiting activities. Cathepsin enzymes are involved in various physiological processes, including protein degradation and immune response regulation. Inhibiting these enzymes can have therapeutic benefits in treating certain diseases, such as cancer and inflammatory conditions.
Used in Biochemical Research:
In the field of biochemical research, N-Boc-1-aminocyclobutanecarboxylic acid serves as a valuable tool for the preparation of alkyl-oxo-aryl amides. These compounds have been identified as novel antagonists of the TRPA1 receptor, which is involved in various sensory processes, including pain perception and ion channel regulation. Modulating the TRPA1 receptor can provide insights into the underlying mechanisms of pain and other sensory responses, potentially leading to the development of new therapeutic strategies for various conditions.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, N-Boc-1-aminocyclobutanecarboxylic acid could potentially be utilized in the development of drug delivery systems. Its unique structure and functional groups may allow for the design of novel carriers or conjugates that can improve the delivery, bioavailability, and therapeutic outcomes of various drugs, particularly those targeting the TRPA1 receptor or related pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 120728-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,7,2 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 120728-10:
(8*1)+(7*2)+(6*0)+(5*7)+(4*2)+(3*8)+(2*1)+(1*0)=91
91 % 10 = 1
So 120728-10-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H17NO4/c1-9(2,3)15-8(14)11-10(7(12)13)5-4-6-10/h4-6H2,1-3H3,(H,11,14)(H,12,13)/p-1
120728-10-1Relevant articles and documents
An Efficient Procedure for Preparation of C- and N-Protected 1-Aminocyclobutane Carboxylic Acid
Kim, June J.,Wood, Michael R.
, p. 607 - 613 (2004)
An efficient method for the synthesis of differentially protected 1-aminocyclobutane carboxylic acid is described. Synthetically useful intermediates 7 and 8 were prepared from ethyl 1-bromocyclobutane-carboxylate in excellent yields (95% and 69%, respectively).
SUBSTITUTED PYRROLIDINE AMIDES V
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Paragraph 0129-0130, (2021/01/22)
The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
C-3 NOVEL TRITERPENONE WITH C-28 REVERSE AMIDE DERIVATIVES AS HIV INHIBITORS
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Page/Page column 51; 52, (2016/11/21)
Formula (I) The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.
