1207354-85-5

Basic information

• Product Name: 9-(4-methoxybenzyl)-2,6-bis(trifluoromethyl)-9H-purine
• Synonyms: 9-(4-methoxybenzyl)-2,6-bis(trifluoromethyl)-9H-purine
• CAS NO: 1207354-85-5
• Molecular Weight: 376.261
• Mol File: 1207354-85-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 9-(4-methoxybenzyl)-2,6-bis(trifluoromethyl)-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(4-methoxybenzyl)-2,6-bis(trifluoromethyl)-9H-purine(1207354-85-5)
• EPA Substance Registry System: 9-(4-methoxybenzyl)-2,6-bis(trifluoromethyl)-9H-purine(1207354-85-5)

Safety Data

• Hazardous Substances Data: 1207354-85-5(Hazardous Substances Data)

Upstream product

• 368-66-1 2,4,6-tris(trifluoromethyl)-1,3,5-triazine 
• 88945-41-9 N-(Cyanmethyl)formimidsaeure-methylester 
• 2393-23-9 4-methoxy-benzylamine 

Relevant articles and documents

Synthesis of fluorinated purine and 1-deazapurine glycosides as potential inhibitors of adenosine deaminase

The synthesis of 2- and 6-trifluoromethylated purines and 1-deazapurines was performed by formal [3 + 3]-cyclization reactions of 5-aminoimidazoles with a set of trifluoromethyl-substituted 1,3-CCC- and 1,3-CNC-dielectrophiles. The corresponding fluorinated nucleosides were synthesized by glycosylation of 9-unsubstituted purines and 1-deazapurines with peracetylated β-ribose, β-glucose, and rhamnose and subsequent deprotection. These scaffolds can be considered as potential inhibitors of adenosine deaminase (ADA) and inosine monophosphate dehydrogenase (IMPDH) enzymes.