1207358-03-9Relevant articles and documents
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity
Koehler, Michael F. T.,Bergeron, Philippe,Blackwood, Elizabeth,Bowman, Krista K.,Chen, Yung-Hsiang,Deshmukh, Gauri,Ding, Xiao,Epler, Jennifer,Lau, Kevin,Lee, Leslie,Liu, Lichuan,Ly, Cuong,Malek, Shiva,Nonomiya, Jim,Oeh, Jason,Ortwine, Daniel F.,Sampath, Deepak,Sideris, Steve,Trinh, Lan,Truong, Tom,Wu, Jiansheng,Pei, Zhonghua,Lyssikatos, Joseph P.
, p. 10958 - 10971 (2013/02/25)
Selective inhibitors of mammalian target of rapamycin (mTOR) kinase based upon saturated heterocycles fused to a pyrimidine core were designed and synthesized. Each series produced compounds with Ki 500-fold sel