120740-10-5

Basic information

• Product Name: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE
• Synonyms: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE;5-Aminomethyl-2-Bromopyridine;(2-Bromo-5-pyridinyl)methylamine;3-Pyridinemethanamine, 6-bromo-;(6-broMopyridin-3-yl)MethanaMine
• CAS NO: 120740-10-5
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.04
• Product Categories: Building Blocks;Pyridine
• Mol File: 120740-10-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 290.1 °C at 760 mmHg
• Flash Point: 129.3 °C
• Appearance: /
• Density: 1.574 g/cm³
• Vapor Pressure: 0.00211mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.74±0.29(Predicted)
• CAS DataBase Reference: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE(120740-10-5)
• EPA Substance Registry System: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE(120740-10-5)

Safety Data

• Hazardous Substances Data: 120740-10-5(Hazardous Substances Data)

Usage

General Description

C-(6-Bromo-pyridin-3-yl)-methylamine, also known as 3-Bromopyridine-1-carboxaldimine, is a chemical compound with the molecular formula C6H7BrN2. C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE belongs to the class of organic compounds known as pyridines and derivatives, which are compounds containing a pyridine ring, a six-membered aromatic heterocycle which consists of two nitrogen atoms and four carbon atoms. The specific properties and characteristics of this compound, such as its reactivity and toxicity, are largely determined by the bromine atom and the amine group in its structure. It is mainly used in the field of pharmaceuticals, biochemistry for scientific and research purposes.

InChI:InChI=1/C6H7BrN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H,3,8H2

Upstream product

• 120740-11-6 C₁₄H₉BrN₂O₂ 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 101990-45-8 2-bromo-5-bromomethylpyridine 
• 139585-70-9 2-bromo-5-cyanopyridine 

Downstream Products

• 1194017-77-0 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-bromo-pyridin-3-ylmethyl)-amide 
• 1448338-04-2 N²-(4-aminocyclohexyl)-N⁶-(6-bromo-pyridin-3-ylmethyl)-9-cyclopentyl-9H-purine-2,6-diamine 
• 1448338-18-8 N²-(4-aminocyclohexyl)-9-cyclopentyl-N⁶-(6-furan-2-yl-pyridin-3-ylmethyl)-9H-purine-2,6-diamine 
• 1448338-14-4 N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine 
• 1448338-15-5 N²-(4-aminocyclohexyl)-N⁶-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine 
• 1448338-16-6 N²-(4-aminocyclohexyl)-N⁶-[6-(2-methoxyphenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine 
• 1448338-19-9 N²-(4-aminocyclohexyl)-9-cyclopentyl-N⁶-(6-furan-3-yl-pyridin-3-ylmethyl)-9H-purine-2,6-diamine 
• 1448338-17-7 N²-(4-aminocyclohexyl)-9-cyclopentyl-N⁶-[6-(3-fluorophenyl)-pyridin-3-ylmethyl]-9H-purine-2,6-diamine 
• 1448338-21-3 N²-(4-aminocyclohexyl)-9-cyclopentyl-N⁶-(6-thiophen-3-yl-pyridin-3-ylmethyl)-9H-purine-2,6-diamine 
• 220339-96-8 5-(aminomethyl)-2,2′-bipyridine 

Relevant articles and documents

Pyridine methylamine compound and preparation method thereof

The invention provides a pyridine methylamine compound and a preparation method thereof. The preparation method comprises the steps that tetrahydrofuran and sodium borohydride are sequentially added into a cyanopyridine compound, then an iodine-containing tetrahydrofuran solution is dropwise added, a reaction is conducted at the temperature of 20-30 DEG C, and after dropwise adding is completed, stirring is carried out continuously; after the reaction is finished, methanol is added for refluxing, extracting and spin-drying are carried out to obtain the pyridine methylamine compound; wherein a functional group in the cyanopyridine compound is selected from chlorine, bromine, methyl, ethyl, amino or hydrogen; according to the preparation method, high-temperature and high-pressure special equipment does not need to be used, so that the preparation method is relatively safe, and dangerous accidents such as explosion and fire disasters are avoided; besides, the preparation method is relatively environment-friendly, recycling treatment of hazardous waste (used Raney nickel) is not involved, the economic benefit is relatively high, borane generated by the synthesis method is converted into boric acid esters in the post-treatment process, the treatment cost is low, and the harm to the environment is much small.

A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors

The inhibition of overactive CDKs during cancer remains an important strategy in cancer drug development. We synthesized and screened a novel series of 2-substituted-6-biarylmethylamino-9-cyclopentylpurine derivatives for improved CDK inhibitory activity and antiproliferative effects. One of the most potent compounds, 6b, exhibited strong cytotoxicity in the human melanoma cell line G361 that correlated with robust CDK1 and CDK2 inhibition and caspase activation. In silico modeling of 6b in the active site of CDK2 revealed a high interaction energy, which we believe is due to the 6-heterobiarylmethylamino substitution of the purine moiety.