1207429-57-9

Basic information

• Product Name: 5-fluoro-2-(4-methylphenyl)benzoxazole
• Synonyms: 5-fluoro-2-(4-methylphenyl)benzoxazole
• CAS NO: 1207429-57-9
• Molecular Weight: 227.238
• Mol File: 1207429-57-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-fluoro-2-(4-methylphenyl)benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2-(4-methylphenyl)benzoxazole(1207429-57-9)
• EPA Substance Registry System: 5-fluoro-2-(4-methylphenyl)benzoxazole(1207429-57-9)

Safety Data

• Hazardous Substances Data: 1207429-57-9(Hazardous Substances Data)

Upstream product

• 36719-51-4 3,3-diethyl-1-(4-methylphenyl)-1-triazene 
• 221347-71-3 5-fluorobenzo[d]oxazole 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 1139705-26-2 4-methylphenyl imidazolesulfonate 
• 106-38-7 para-bromotoluene 

Relevant articles and documents

Synthesis of N-heterocyclic carbene-PdCl-[(2-Pyridyl)alkyl carboxylate] complexes and their catalytic activities towards arylation of (benzo)oxazoles with aryl bromides

Four well-defined N-heterocyclic carbene-PdCl-[(2-Pyridyl)alkyl carboxylate] complexes have been conveniently synthesized through bridge-cleavage reactions of [Pd(μ-Cl)(Cl)(NHC)]2 with (2-pyridyl)alkyl carboxylic acids [2-(pyridin-2-yl)acetic acid and 3-(pyridin-2-yl)propanoic acid]. The new complexes have been fully characterized by NMR, elemental analysis, HR-MS and X-ray single-crystal diffraction. The catalytic performance of the complexes was screened and the obtained palladium (II) complexes shown effective catalytic activities for direct arylation of (benzo)oxazoles with aryl bromides. Moreover, the 2-(pyridin-2-yl)acetate stabilized NHC–Pd complexes were more efficient than the 3-(pyridin-2-yl)propanoate stabilized NHC–Pd analogues. Further studies exhibited that 2-(pyridin-2-yl)acetate, as ancillary ligand, could easily decarboxylate and transform into 2-methylpyridine in the reaction condition.

Direct oxidative C-H arylation of benzoxazoles with arylsulfonyl hydrazides promoted by palladium complexes

This study describes a direct oxidative C-2 arylation of benzoxazoles using arylsulfonyl hydrazides as the aryl sources. A simple catalyst system [Pd(OAc)2 and Ph3P] allows the reactions to proceed smoothly under oxidative reaction conditions. Other heteroarenes such as caffeine and benzothiazole are also applicable substrates. Notably, this catalytic system tolerates halogen substituents which provides a useful complement to the current cross-coupling reactions which use aryl halides.

Palladium-catalyzed direct arylations, alkenylations, and benzylations through C-H bond cleavages with sulfamates or phosphates as electrophiles

(Figure Presented) catalytic system comprised of Pd(OAc)2 and bldentate ligand dppe enabled first direct arylatlons with moisture-stable aryl sulfamates as electrophlles, and proved applicable to unprecedented C-H bond functlonallzations with e