1207548-70-6

Basic information

• Product Name: 4-(4-chlorophenyl)-6-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one
• Synonyms: 4-(4-chlorophenyl)-6-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one
• CAS NO: 1207548-70-6
• Molecular Weight: 390.869
• Mol File: 1207548-70-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-chlorophenyl)-6-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-6-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one(1207548-70-6)
• EPA Substance Registry System: 4-(4-chlorophenyl)-6-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one(1207548-70-6)

Safety Data

• Hazardous Substances Data: 1207548-70-6(Hazardous Substances Data)

Upstream product

• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 104-88-1 4-chlorobenzaldehyde 
• 57-13-6 urea 

Relevant articles and documents

Bronsted base-catalyzed one-pot three-component Biginelli-type reaction: An efficient synthesis of 4,5,6-triaryl-3,4-dihydropyrimidin-2(1H)-one and mechanistic study

(Chemical Equation Presented) An efficient one-pot synthesis of 4,5,6-triaryl-3,4-dihydropyrimidin-2(1H)-ones via a three-component Biginelli-type condensation of aldehyde, 2-phenylacetophenone, and urea/thiourea in the presence of a catalytic amount of t-BuOK (20 mol %) is described. The reactions proceeded efficiently at 70 °C to afford the desired products in moderate to good yields. Detailed mechanistic study shows that the Biginelli-type reaction using urea and thiourea proceeds through two totally different pathways. Enone 5 and bis-urea 8 were highly suggested as respective reaction intermediates for reactions involving thiourea and urea as substrates.