1207714-41-7Relevant articles and documents
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of Type-2 diabetes
Kitas, Eric,Mohr, Peter,Kuhn, Bernd,Hebeisen, Paul,Wessel, Hans Peter,Haap, Wolfgang,Ruf, Armin,Benz, Joerg,Joseph, Catherine,Huber, Walter,Sanchez, Ruben Alvarez,Paehler, Axel,Benardeau, Agnes,Gubler, Marcel,Schott, Brigitte,Tozzo, Effie
scheme or table, p. 594 - 599 (2010/05/19)
Sulfonylureido thiazoles were identified from a HTS campaign and optimized through a combination of structure-activity studies, X-ray crystallography and molecular modeling to yield potent inhibitors of fructose-1,6-bisphosphatase. Compound 12 showed favo