1207748-36-4

Basic information

• Product Name: ethyl N-benzyl-8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS NO: 1207748-36-4
• Molecular Weight: 325.339
• Mol File: 1207748-36-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl N-benzyl-8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-benzyl-8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate(1207748-36-4)
• EPA Substance Registry System: ethyl N-benzyl-8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate(1207748-36-4)

Safety Data

• Hazardous Substances Data: 1207748-36-4(Hazardous Substances Data)

Upstream product

• 71083-06-2 ethyl 8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 100-44-7 benzyl chloride 
• 63010-68-4 diethyl [(2-fluoroanilino)methylidene]malonate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 348-54-9 2-Fluoroaniline 

Relevant articles and documents

A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy

The investigation of the mode and time course of the activation of G-protein-coupled receptors (GPCRs), in particular muscarinic acetylcholine (mACh or M) receptors, is still in its infancy despite the tremendous therapeutic relevance of M receptors and GPCRs in general. We herein made use of a dualsteric ligand that can concomitantly interact with the orthosteric, that is, the neurotransmitter, binding site and an allosteric one. We synthetically incorporated a photoswitchable (photochromic) azobenzene moiety. We characterized the photophysical properties of this ligand called BQCAAI and investigated its applicability as a pharmacological tool compound with a set of FRET techniques at the M1 receptor. BQCAAI proved to be an unprecedented molecular tool; it is the first photoswitchable dualsteric ligand, and its activity can be regulated by light. We also applied BQCCAI to investigate the time course of several receptor activation processes.