1207853-61-9

Basic information

• Product Name: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine
• Synonyms: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine;tert-butyl (3R,4R)-3-amino-4-methylpiperidine-1-carboxylate
• CAS NO: 1207853-61-9
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30458
• Mol File: 1207853-61-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.009±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 10.37±0.40(Predicted)
• CAS DataBase Reference: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine(1207853-61-9)
• EPA Substance Registry System: (3R,4R)-3-AMino-1-Boc-4-Methylpiperidine(1207853-61-9)

Safety Data

• Hazardous Substances Data: 1207853-61-9(Hazardous Substances Data)

Usage

General Description

(3R,4R)-3-Amino-1-Boc-4-Methylpiperidine is a chemical compound with the molecular formula C12H24N2O2. It is a derivative of piperidine, a heterocyclic organic compound, and contains an amino group and a Boc (tert-butoxycarbonyl) protecting group. The (3R,4R) stereochemistry indicates the specific conformation of the compound. It is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds due to its versatile reactivity and potential for various functional group transformations. Additionally, its specific structure and properties make it valuable for research and development in the fields of medicinal chemistry and organic synthesis.

Upstream product

• 374794-77-1 tert-butyl 4-methyl-3-oxopiperidine-1-carboxylate 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 175406-94-7 1-benzyl-3-oxopiperidine-4-carboxylic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1271810-25-3 trans 1-(tert-butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid 
• 1201192-62-2 1-(tert-butyl) 3-methyl 4-methylpiperidine-1,3-dicarboxylate 
• 908244-98-4 methyl 4-methylpiperidine-3-carboxylate 
• 33402-75-4 4-methylnicotinic acid methyl ester 
• 3222-50-2 4-methylnicotinic acid 

Downstream Products

• 1312762-44-9 (3R,4R)-3-methylamino-4-methylpiperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION

This invention is in the area of heterocyclic-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

(3S, 4R) - 3-amino-4-methyl-piperidin-1-carboxylic acid tert-butyl ester preparation method

The invention discloses a high-stereoselectivity preparation method of (3S, 4R)-3-amido-4-methyl piperidine-1-tertiary butyl carboxylate, which is mainly used for solving the problems that compounds reported by conventional documents have long synthesis routes and poor stereoselectivity. The preparation method comprises the following steps: carrying out ylide reaction under an alkaline condition by taking a compound R)-1-(1-tert-butyloxycarbonyl)-4-oxo-3-piperidyl hydrazine-1,2-dibenzyl dicarboxylate as a starting material to obtain (S)-1-(1-tert-butyloxycarbonyl)-4-methylene -3-piperidyl hydrazine-1,2-dibenzyl dicarboxylate; then, obtaining (3S, 4R)-3- diazanyl-4-methyl piperidine-1-tertiary butyl carboxylate by catalytic hydrogenation under action of a metal hydrogenation catalyst and hydrogen gas; and finally, reducing under action of the metal hydrogenation catalyst and hydrogen gas to obtain the (3S, 4R)-3-amido-4-methyl piperidine-1-tertiary butyl carboxylate. And the total yield is 34.5%.

BRUTON'S TYROSINE KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.