1208110-11-5

Basic information

• Product Name: (2S)-6-methoxy-1'-[2-(3-methoxyphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride
• Synonyms: (2S)-6-methoxy-1'-[2-(3-methoxyphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride
• CAS NO: 1208110-11-5
• Molecular Weight: 415.96
• Mol File: 1208110-11-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-6-methoxy-1'-[2-(3-methoxyphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-6-methoxy-1'-[2-(3-methoxyphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride(1208110-11-5)
• EPA Substance Registry System: (2S)-6-methoxy-1'-[2-(3-methoxyphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride(1208110-11-5)

Safety Data

• Hazardous Substances Data: 1208110-11-5(Hazardous Substances Data)

Upstream product

• 2471-71-8 (2RS)-N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 
• 20933-24-8 2-bromo-6-methoxy-1-tetralone 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 173272-95-2 (2RS)-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one 
• 25112-95-2 toluene-4-sulfonic acid 2-(3-methoxyphenyl)-ethyl ester 
• 5020-41-7 2-(3-methoxyphenyl)-ethanol 
• 18927-05-4 methyl (3-methoxyphenyl)acetate 
• 1798-09-0 m-methoxyphenylacetic acid 
• 1208110-09-1 (2S)-6-methoxy-1'-[2-(3-methoxyphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one 
• 25226-97-5 3-methoxyphenethyl iodide 
• 78348-46-6 N-benzoyl-2-piperidinecarboxylic acid 
• 71413-04-2 (2RS)-1-benzoylpiperidine-2-carbonitrile 

Relevant articles and documents

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers

With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H+,K+-ATPase and can strongly bind to the K+-binding site, were designed based on a docking model. Among the compounds synthesized, compound 4d showed a strong H+,K+-ATPase-inhibitory activity and a high stomach concentration in rats, resulting in potent inhibitory action on histamine-stimulated gastric acid secretion in rats. Furthermore, 4d exerted significant inhibitory action on histamine-stimulated gastric-acid secretion in rats with a rapid onset and moderate duration of action after the administration. These findings may lead to a new insight into the drug design of potassium-competitive acid blockers.