1208260-67-6Relevant articles and documents
Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P1) receptor agonists
Zecri, Frederic J.,Albert, Rainer,Landrum, Gregory,Hinterding, Klaus,Cooke, Nigel G.,Guerini, Danilo,Streiff, Markus,Bruns, Christian,Nuesslein-Hildesheim, Barbara
scheme or table, p. 35 - 37 (2010/05/02)
High throughput screening and hit to lead optimization led to the identification of 'carene' as a promising scaffold showing selective S1P1 receptor agonism. In parallel to this work we have established a pharmacophore model for the S1P1 receptor highlighting the minimal structural requirement necessary for potent receptor agonism.
