120914-45-6

Basic information

• Product Name: 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzamide
• CAS NO: 120914-45-6
• Molecular Weight: 319.286
• Mol File: 120914-45-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzamide(120914-45-6)
• EPA Substance Registry System: 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzamide(120914-45-6)

Safety Data

• Hazardous Substances Data: 120914-45-6(Hazardous Substances Data)

Upstream product

• 120914-42-3 7-methyl-10-(trifluoromethyl)-7H-isoindolo<2,1-b>-1,2,4-benzotriazin-5-one 
• 120914-46-7 12-methyl-9-(trifluoromethyl)-12H-benzimidazo<2,1-a>-phthalazine-5-one 
• 85-44-9 phthalic anhydride 
• 120940-45-6 2,4,6-Trimethyl-benzenesulfonate1-amino-2-(2-ethoxycarbonyl-phenyl)-3-methyl-6-trifluoromethyl-3H-benzoimidazol-1-ium; 
• 35203-49-7 N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine 
• 120914-48-9 ethyl 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzoate 
• 120914-47-8 N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid 

Relevant articles and documents

Synthesis and Thermal Reactions of 1,2-Dihydro-1,2,4-benzotriazines

The 1,2-dimethyl-1,2,4-benzotriazines (7),(8), and (9) were prepared by acid-catalysed cyclisation of the 2-aminophenylhydrazine derivatives derived from (12), (13), and (14) respectively.Compounds (7) and(9) undergo a thermal elimination to fully aromatic benzotriazines.However, the 2-acyl derivative (18) rearranges to the thermodynamically more stable 4-acyl compound (21).In the presence of traces of water, a ring contraction to benzimidazoles is a competing reaction.For (18) the nitrogen fragment is retained in the benzamide (22).A mechanism for the ring contraction has been suggested in which initial hydration of the imine bond gives 1,2,3,4-tetrahydrobenzotriazines which ring-open, then re-cyclise to benzimidazoles.The benzimidazophthalazine (23) was shown not to be an intermediate in the water-mediated ring contraction of (18).