120977-75-5

Basic information

• Product Name: N-(2-fluoroethyl)-N-methyl-aniline
• Synonyms: N-(2-fluoroethyl)-N-methyl-aniline
• CAS NO: 120977-75-5
• Molecular Weight: 153.199
• Mol File: 120977-75-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-fluoroethyl)-N-methyl-aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluoroethyl)-N-methyl-aniline(120977-75-5)
• EPA Substance Registry System: N-(2-fluoroethyl)-N-methyl-aniline(120977-75-5)

Safety Data

• Hazardous Substances Data: 120977-75-5(Hazardous Substances Data)

Upstream product

• 93-90-3 N-(2-hydroxyethyl)-N-methylaminobenzene 
• 100-61-8 N-methylaniline 
• 29182-97-6 N-methyl-2-bromoacetanilide 
• 762-49-2 2-fluoroethyl bromide 
• 35954-01-9 lithium N-methylanilide 

Relevant articles and documents

Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride

An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerates nucleophilic fluorinations using easy handling KF. We also successfully converted an inexpensive and commercially available ion-exchange resin to the polymer-supported ion pair promoter (A26–SO42–), which could be reused after filtration. Moreover, A26–SO42– can be used in continuous flow conditions. In our conditions, water is well-tolerated.

Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks

Anodic methoxylation of various types of N-(fluoroethyl)amines, ArRNCH2Rf (Rf = CF3, CHF2, CH2F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position α to the fluoromethyl (Rf) group, depending on the Rf and R groups.The effect of the Rf group on the promotion of the anodic α-methoxylation decreased in the order CF3, CHF2, and CH2F.This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines.The α-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds α to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods.