121020-94-8Relevant articles and documents
Kinetics and mechanism of degradation of cefotaxime sodium in aqueous solution
Berge,Henderson,Frank
, p. 59 - 63 (1983)
The degradation kinetics and mechanism of a potent new cephalosporin, cefotaxime sodium, in aqueous solution were investigated at pH 0-10 at 25° and an ionic strength of 0.5. The degradation rates were determined by high-pressure liquid chromatography and were observed to follow pseudo first-order kinetics with respect to cefotaxime sodium concentration. The data suggested that the rate of degradation was influenced significantly by solvolytic, hydrogen ion, and hydroxide ion catalysis. No primary salt effects were observed in the acid or neutral regions; however, a positive salt effect was observed at pH 8.94. Buffer catalysis due to the buffer species employed was not seen during the kinetic studies. The pH-rate profile at 25° indicated that the maximum stability of cefotaxime sodium occurred in the pH 4.5-6.5 region. In aqueous solution, cefotaxime was shown to degrade by two parallel reactions; de-esterification at the C-3 position and β-lactam cleavage. Good agreement between the the theoretical pH-rate profile and the experimental data support the proposed degradation process.
Intermediates in the synthesis of cephalosporins
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, (2008/06/13)
Novel amidine salts of 7-Amino-3-hydroxymethyl-3-cephem-4-carboxylic acid (=HACA), particular guanidine and diaza-bicyclo-alkylene salts, are useful as intermediates in the synthesis of cephalosporins.
Cephem compounds, their production and use
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, (2008/06/13)
This invention relates to a compound of the formula: STR1 wherein Q is nitrogen or CH; R1 is hydrogen or a lower alkyl group which may be substituted; and ring A is a pyridine or pyridazine ring which is substituted at the ring-constituting car