121031-01-4Relevant articles and documents
Syntheses and antibacterial activity of N -acylated ciprofloxacin derivatives based on the trimethyl lock
Ji, Cheng,Miller, Patricia A.,Miller, Marvin J.
, p. 707 - 710 (2015)
Several N-acyl ciprofloxacin quinone derivatives based on a trimethyl lock structure were synthesized, and their in vitro antibacterial activity against a panel of clinically relevant bacteria was evaluated. A few new analogues displayed enhanced activity
Water-soluble triptolide derivative and preparation method and application thereof
-
, (2019/08/20)
The invention discloses a water-soluble triptolide derivative and a preparation method and application thereof. The chemical structural formula of the water-soluble triptolide derivative is as shown in the specification, wherein n=2,3,4..., and n is a pos
Reductive activation of conformationally-constrained, anticancer drug delivery systems
Gharat, Laxmikant,Visser, Petra,Brummelhuis, Mathijn,Guiles, Ronald,Chikhale, Prashant
, p. 444 - 456 (2007/10/03)
Redox-active substituents were used to modulate reduction potentials in conformationally-constrained, drug delivery systems. The extent of drug delivery was proportional to the degree of reductive activation, which was influenced by the electronic properties of the substituents. Such reductively-activated carrier systems can be used to achieve controlled drug delivery to bioreductive regions in hypoxic solid tumors.