121204-87-3 Usage
Description
H-ALA-SER-ALA-SER-SER-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH, also known as [Ala1,3,11,15]-Endothelin 1, is a linear endothelin (ET)-1 analogue that acts as an ETB receptor agonist. It is a peptide that functions as both a vasodilator and a vasoconstrictor, making it a significant ligand for the ET receptor system, which consists of two types, ETA and ETB. The ETB receptor is predominantly located in the vascular endothelial cells of cardiovascular tissues.
Uses
Used in Pharmaceutical Research:
[Ala1,3,11,15]-Endothelin 1 is utilized in pharmaceutical research to evaluate the effects of endothelin-1 and its analogues produced by ETA and ETB receptors. This is particularly relevant in the presence of BQ-123, a selective ETA receptor antagonist, in anaesthetized rat models. The analogue provides insights into the complex interactions between endothelin-1 and its receptors, which can be crucial for developing targeted therapies for various cardiovascular conditions.
Used in Cardiovascular Research:
In cardiovascular research, [Ala1,3,11,15]-Endothelin 1 serves as a valuable tool for studying the role of ETB receptors in vascular function. By examining the effects of this analogue on vasodilation and vasoconstriction, researchers can better understand the underlying mechanisms of various cardiovascular diseases and develop more effective treatments.
Used in Drug Development:
The analogue [Ala1,3,11,15]-Endothelin 1 may also be employed in the development of new drugs targeting the endothelin system. By modulating the activity of ET receptors, particularly the ETB receptor, it may be possible to create medications that treat a range of cardiovascular disorders, including hypertension, heart failure, and pulmonary arterial hypertension.
Biochem/physiol Actions
Selective agonist for ETB endothelin receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 121204-87-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,2,0 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 121204-87:
(8*1)+(7*2)+(6*1)+(5*2)+(4*0)+(3*4)+(2*8)+(1*7)=73
73 % 10 = 3
So 121204-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C109H163N25O32S/c1-16-56(9)86(113)104(159)134-88(57(10)17-2)106(161)129-78(43-64-47-115-69-28-22-21-27-67(64)69)108(163)166-109(164)79(46-84(141)142)128-97(152)72(39-53(3)4)124-99(154)75(44-65-48-114-52-116-65)122-90(145)59(12)118-96(151)73(41-62-25-19-18-20-26-62)125-98(153)74(42-63-30-32-66(138)33-31-63)126-105(160)87(55(7)8)133-92(147)61(14)117-94(149)71(121-95(150)70(29-23-24-37-110)120-100(155)76(45-83(139)140)123-93(148)68(112)36-38-167-15)34-35-85(143)165-107(162)77(40-54(5)6)127-102(157)82(51-137)132-103(158)81(50-136)131-91(146)60(13)119-101(156)80(49-135)130-89(144)58(11)111/h18-22,25-28,30-33,47-48,52-61,65,68,70-82,86-88,115,135-138H,16-17,23-24,29,34-46,49-51,110-113H2,1-15H3,(H,117,149)(H,118,151)(H,119,156)(H,120,155)(H,121,150)(H,122,145)(H,123,148)(H,124,154)(H,125,153)(H,126,160)(H,127,157)(H,128,152)(H,129,161)(H,130,144)(H,131,146)(H,132,158)(H,133,147)(H,134,159)(H,139,140)(H,141,142)/t56-,57-,58-,59-,60-,61-,65?,68-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,86-,87-,88-/
