121367-05-3 Usage
Description
(S)-(+)-DIMETHINDENE MALEATE is a chemical compound that acts as a subtype-selective muscarinic acetylcholine receptor M2 (mAChR M2) antagonist and histamine H1 receptor antagonist. It is known for its ability to selectively target specific receptors, which can be beneficial in various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
(S)-(+)-DIMETHINDENE MALEATE is used as a therapeutic agent for treating conditions that involve the muscarinic acetylcholine receptor M2 and histamine H1 receptor pathways. Its subtype-selective antagonism allows for targeted treatment with potentially fewer side effects compared to non-selective antagonists.
Used in Research Applications:
In the field of research, (S)-(+)-DIMETHINDENE MALEATE serves as a valuable tool for studying the roles and interactions of mAChR M2 and histamine H1 receptors in various physiological and pathological processes. This can help scientists better understand the mechanisms underlying certain diseases and develop more effective treatments.
Used in Drug Development:
(S)-(+)-DIMETHINDENE MALEATE can be utilized in the development of new drugs targeting the mAChR M2 and histamine H1 receptors. Its subtype selectivity and antagonistic properties make it a promising candidate for the creation of novel medications with improved efficacy and reduced side effects.
Biological Activity
Enantiomer that is a subtype-selective M 2 muscarinic receptor antagonist (pK i values are 7.08, 7.78, 6.70 and 7.00 for M 1 , M 2 , M 3 and M 4 receptors respectively). Also H 1 histamine receptor antagonist (pK i = 7.48).
Check Digit Verification of cas no
The CAS Registry Mumber 121367-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,3,6 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 121367-05:
(8*1)+(7*2)+(6*1)+(5*3)+(4*6)+(3*7)+(2*0)+(1*5)=93
93 % 10 = 3
So 121367-05-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t15-;/m1./s1
121367-05-3Relevant articles and documents
Metabolism of dimetindene in rats
Radler,Wermeille,Blaschke
, p. 1086 - 1092 (2007/10/02)
The preparative separation of dimetindene (CAS 5636-83-9) enantiomers was achieved by fractionated crystallization of the diastereomeric tartrate salts. HPLC on α-AGP (α1-acid glycoprotein) was used for confirmation of the enantiomeric purity.
