1214265-80-1

Basic information

• Product Name: (R)-4-(7-cyano-6-ethyl-5-isopropyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid
• Synonyms: (R)-4-(7-cyano-6-ethyl-5-isopropyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid
• CAS NO: 1214265-80-1
• Molecular Weight: 451.46
• Mol File: 1214265-80-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-4-(7-cyano-6-ethyl-5-isopropyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(7-cyano-6-ethyl-5-isopropyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid(1214265-80-1)
• EPA Substance Registry System: (R)-4-(7-cyano-6-ethyl-5-isopropyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid(1214265-80-1)

Safety Data

• Hazardous Substances Data: 1214265-80-1(Hazardous Substances Data)

Upstream product

• 889877-77-4 (7R)-2-chloro-7-ethyl-8-(propan-2-yl)-7,8-dihydropteridin-6(5H)-one 
• 946161-16-6 methyl (2R)-2-[(2-chloro-5-nitropyrimidin-4-yl)(propan-2-yl)amino]butanoate 
• 947667-22-3 Methyl (2R)-2-(isopropylamino) butanoate 
• 1001346-91-3 4-amino-2-fluoro-5-methoxy-benzoic acid 
• 1214265-79-8 (6R)-3-chloro-6-ethyl-5-(propan-2-yl)-5,6-dihydroimidazo[1,5-f]pteridine-7-carbonitrile 

Relevant articles and documents

Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors

Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine PLK1 inhibitors. Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, and oral bioavailability. Compound 1 exhibits >7 fold induction of phosphorylated Histone H3 and is efficacious in an in vivo HT-29 tumor xenograft model.