121432-12-0

Basic information

• Product Name: Methyl 5-oxazolecarboxylate
• Synonyms: Methyl 1,3-oxazole-5-carboxylate;Methyl oxazol-5-carboxylate;5-Oxazolecarboxylic acid, methyl ester (9CI);Methyl 5-oxazolecarboxylate.;5-Oxazolecarboxylic acid methyl ester;Methyl 5-oxazolecarboxylate,96%;oxazole-5-carboxylic acid methyl ester
• CAS NO: 121432-12-0
• Molecular Formula: C₅H₅NO₃
• Molecular Weight: 127.1
• Product Categories: ACIDHALIDE
• Mol File: 121432-12-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 44-46 °C
• Boiling Point: 184 °C at 760 mmHg
• Flash Point: 65.1 °C
• Appearance: /
• Density: 1.229 g/cm³
• Vapor Pressure: 0.751mmHg at 25°C
• Refractive Index: 1.462
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.19±0.10(Predicted)
• CAS DataBase Reference: Methyl 5-oxazolecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-oxazolecarboxylate(121432-12-0)
• EPA Substance Registry System: Methyl 5-oxazolecarboxylate(121432-12-0)

Safety Data

• Hazardous Substances Data: 121432-12-0(Hazardous Substances Data)

Usage

General Description

Methyl 5-oxazolecarboxylate is a chemical compound with the molecular formula C6H5NO3. It is an ester derived from the oxazolecarboxylic acid, and it is commonly used as a building block in organic synthesis. Methyl 5-oxazolecarboxylate has a variety of applications, including as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the synthesis of biologically active molecules and as a reagent in organic reactions. The compound is typically handled and stored with caution, as it may be harmful if swallowed, inhaled, or in contact with skin.

InChI:InChI=1/C5H5NO3/c1-8-5(7)4-2-6-3-9-4/h2-3H,1H3

Upstream product

• 67-56-1 methanol 
• 924-44-7 glyoxylic acid ethyl ester 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 

Downstream Products

• 934236-41-6 methyl 2-chloro-1,3-oxazole-5-carboxylate 
• 1254036-82-2 methyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 127232-41-1 1,3-oxazol-5-ylmethanol 

Relevant articles and documents

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.

A NEW PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS

The present invention relates to a process for synthesizing in good yield substituted 2- aminoaryloxazole compounds of formula I which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit, bcr-abl, Flt-3 and mutant forms thereof