121453-41-6

Basic information

• Product Name: <2-(4-bromophenyl)ethoxy>dimethyl(1,1,2-trimethylpropyl)silane
• Synonyms: <2-(4-bromophenyl)ethoxy>dimethyl(1,1,2-trimethylpropyl)silane
• CAS NO: 121453-41-6
• Molecular Weight: 343.379
• Mol File: 121453-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: <2-(4-bromophenyl)ethoxy>dimethyl(1,1,2-trimethylpropyl)silane(CAS DataBase Reference)
• NIST Chemistry Reference: <2-(4-bromophenyl)ethoxy>dimethyl(1,1,2-trimethylpropyl)silane(121453-41-6)
• EPA Substance Registry System: <2-(4-bromophenyl)ethoxy>dimethyl(1,1,2-trimethylpropyl)silane(121453-41-6)

Safety Data

• Hazardous Substances Data: 121453-41-6(Hazardous Substances Data)

Upstream product

• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 4654-39-1 4-bromophenethanol 
• 67373-56-2 chlorodimethyl(1,1,2-trimethylpropyl)silane 

Downstream Products

• 135613-34-2 <1S-1α,2α,3α,4α>-4-<2-<3-<<<(phenylamino)carbonyl>hydrazono>methyl>-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid 
• 135613-35-3 <1S-1α,2α,3α,4α>-4-<<3-<<<(phenylamino)carbonyl>hydrazono>methyl>-7-oxabicyclo<2.2.1>hept-2-yl>methyl>benzeneacetic acid 
• 135613-40-0 Acetic acid (1R,2R,3R,4S)-3-(4-{2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester 
• 135613-41-1 [4-((1S,2R,3R,4R)-3-Acetoxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-acetic acid methyl ester 
• 135639-13-3 [(1R,2R,3R,4S)-3-(4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol 
• 135613-42-2 <1S-1α,2α,3α,4α>-4-<<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>methyl>benzeneacetic acid, methyl ester 
• 135613-38-6 <1S-1α,2α,3α,4α>-4-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester 
• 135613-39-7 (4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol 

Relevant articles and documents

Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone ω-chains

A series of chiral interphenylene 7-oxabicyclo[2.2.1]heptane semicarbazones 19-26 were prepared and evaluated for their in vitro thromboxane (TxA2) antagonistic activity and in vivo duration of action. The potency of 19-26 was found to be highly dependent on the substitution pattern of the interphenylene ring and decreased in the order ortho > meta >> para. SQ 35,091 (25), [1S-(1α,2α,3α,4α)]-2-[[3-[[[(phenylamino)carbonyl]hydrazono] methyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]benzenepropanoic acid, was identified as a potent and long-acting TxA2 antagonist. In human platelet rich plasma SQ 35,091 inhibited arachidonic acid (800 μM) and U-46,619 (10 μM) induced aggregation with I50 values of 3 and 12 nM, respectively. In contrast, no inhibition of ADP (20 μM) induced aggregation was observed at >1000 μM. Receptor binding studies with [3H]-SQ 29,548 showed SQ 35,091 was a competitive antagonist with a K(d) value of 1.0 ± 0.1 nM in human platelet membranes. In vivo SQ 35,091 (0.2 mg/kg po) showed extended protection (T50 = 16 h) from U-46,619 (2 mg/kg iv) induced death in mice. These compounds have for the first time demonstrated that a metabolically stable interphenylene α-sidechain can be introduced into a prostanoid-like series of TxA2 antagonists with the maintenance of potent antagonistic activity.