1214740-37-0Relevant articles and documents
In vitro cytotoxic evaluation of some new heterocyclic sulfonamide derivatives
Ghorab, Mostafa M.,Al-Said, Mansour S.,El-Hossary, Ebaa M.
experimental part, p. 563 - 571 (2011/07/30)
Sulfonamide-bearing compounds posses many types of biological activities and have been recently reported to show substantial antitumor activity in vitro and/or in vivo. There are a variety of mechanisms for the anticancer activity, and the most prominent
Discovering some novel tetrahydroquinoline derivatives bearing the biologically active sulfonamide moiety as a new class of antitumor agents
Alqasoumi, Saleh I.,Al-Taweel, Areej M.,Alafeefy, Ahmed M.,Ghorab, Mostafa M.,Noaman, Eman
experimental part, p. 1849 - 1853 (2010/06/17)
The present article describes the synthesis of some novel 4-(2-amino-3-cyano-4-(substituted-aryl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(4H)-yl)benzenesulfonamide (23-41) starting with 4-(3-oxo-cyclohex-1-enylamino)benzenesulfonamide (3). All the newly synthesized compounds were evaluated for their in vitro antitumor activity. Compounds 32, 25, 41, 35, 33, and 37 with IC50 values (2.5, 3, 5, 10, 12, and 12.5 μg/mL) are more potent and efficacious than Doxorubicin (CAS-23214-92-8) as reference drug with (IC50 value = 37.5 μg/mL). Also, compounds 28, 30, 31, and 34 (with IC50 values = 25 μg/mL) are nearly as active as Doxorubicin.