1214899-85-0

Basic information

• Product Name: 6-bromo-1-methyl-1H-indazol-3-amine
• Synonyms: 6-bromo-1-methyl-1H-indazol-3-amine;3-Amino-6-bromo-1-methyl-1H-indazole
• CAS NO: 1214899-85-0
• Molecular Formula: C₈H₈BrN₃
• Molecular Weight: 226.07322
• Mol File: 1214899-85-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 378.443 °C at 760 mmHg
• Flash Point: 182.676 °C
• Appearance: /
• Density: 1.763 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.12±0.50(Predicted)
• CAS DataBase Reference: 6-bromo-1-methyl-1H-indazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-1-methyl-1H-indazol-3-amine(1214899-85-0)
• EPA Substance Registry System: 6-bromo-1-methyl-1H-indazol-3-amine(1214899-85-0)

Safety Data

• Hazardous Substances Data: 1214899-85-0(Hazardous Substances Data)

Usage

General Description

6-Bromo-1-methyl-1H-indazol-3-amine is a chemical compound with the molecular formula C9H8BrN3. It is a derivative of indazole, a heterocyclic aromatic organic compound. This chemical is used in medicinal chemistry for the synthesis of various biologically active compounds and pharmaceutical drugs. It is also used as a building block in the development of potential anticancer and antimicrobial agents due to its structural characteristics and potential pharmacological properties. The compound may also have applications in other areas of research and development, particularly in the field of organic synthesis and drug discovery.

Upstream product

• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 60-34-4 methylhydrazine 
• 404827-77-6 ethyl 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl)benzoate 
• 74-88-4 methyl iodide 

Downstream Products

• 1429869-67-9 5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one 

Relevant articles and documents

ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR

The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

A general, one-step synthesis of substituted indazoles using a flow reactor

Flow chemistry is a rapidly emerging technology within the pharmaceutical industry, both within medicinal and development chemistry groups. The advantages of flow chemistry, increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technology in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilises flow chemistry to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogues.