1214914-30-3Relevant articles and documents
A new strategy for the synthesis of fluorinated 3,4-dihydropyrimidinones
Fustero, Santos,Catalán, Silvia,Ace?a, José Luis,del Pozo, Carlos
experimental part, p. 1145 - 1150 (2010/03/01)
A new family of 3,4-dihydropyrimidinones (DHPMs) bearing fluorinated substituents at C6 have been prepared from gem-difluorinated nitriles, alkyl 3-butenoates and iso(thio)cyanates. This novel Biginelli-type process relies on the γ-addition of the ester-derived enolate to fluorinated nitriles. A tandem nucleophilic addition aza-Michael reaction sequence completes the synthetic process.