121492-10-2

Basic information

• Product Name: (2-HYDROXY-ETHYL)-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (2-HYDROXY-ETHYL)-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER;TERT-BUTYL (2-HYDROXYETHYL)PHENYLCARBAMATE
• CAS NO: 121492-10-2
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.29
• Mol File: 121492-10-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-HYDROXY-ETHYL)-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HYDROXY-ETHYL)-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER(121492-10-2)
• EPA Substance Registry System: (2-HYDROXY-ETHYL)-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER(121492-10-2)

Safety Data

• Hazardous Substances Data: 121492-10-2(Hazardous Substances Data)

Usage

General Description

(2-Hydroxy-ethyl)-phenyl-carbamic acid tert-butyl ester is a chemical compound with the molecular formula C13H19NO3. It is commonly used as a reagent in organic synthesis and pharmaceutical research. (2-HYDROXY-ETHYL)-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER is a tert-butyl ester derivative of phenylcarbamic acid, and its unique structure makes it useful for various applications in the field of chemistry. It is known for its role as a building block in the synthesis of organic compounds, and its properties make it suitable for use as a protective group for certain functional groups in organic synthesis. Additionally, it has potential pharmacological activity and is being studied for its potential use in the development of new drugs.

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Downstream Products

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Relevant articles and documents

Preparation, characterization and application of 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2]·2Cl) as an efficient dicationic ionic catalyst for the N-Boc protection of amines

In this work, 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2]·2Cl), as a novel Br?nsted acidic ionic catalyst is synthesized and characterized using a series of techniques including FT-IR, TGA, DTA, SEM, pH analysis and Hammett acidity function. This substance can significantly catalyze the N-Boc protection of amines without solvent interference at room temperature. The advantages of this manner are chemoselectivity, short reaction times, suitable yields, excellent yields of the products, without solvent interference and ease of preparation as well as reusability of the catalyst.

Silver-Catalyzed Three-Component 1,1-Aminoacylation of Homopropargylamines: α-Additions for Both Terminal Alkynes and Isocyanides

The reaction of secondary homopropargylamines, isocyanides, and water in the presence of a catalytic amount of silver acetate and subsequent purification by chromatography on silica gel afforded substituted proline amides in good to excellent yields. Primary homopropargylamines underwent a cyclizative Ugi–Joullié three-component reaction with isocyanides and carboxylic acids to afford functionalized N-acyl proline amides. High diastereoselectivity was observed in the synthesis of 4-alkoxy and 4,5-disubstituted proline derivatives. This work represents the first examples of a three-component cyclizative 1,1-aminoacylation of terminal alkynes.

CONTROLLED HNO RELEASE THROUGH INTRAMOLECULAR CYCLIZATION-ELIMINATION

Protected HNO donors designed to undergo non-enzymatic release at neutral pH via an intramolecular cyclization-elimination are disclosed. The rate of cyclization, and therefore HNO release, can be controlled by substituents and chain length. Thus, biologi