1215004-65-1

Basic information

• Product Name: (2-phenyl-1H-indol-3-yl)(thiophen-2-yl)methanone
• Synonyms: (2-phenyl-1H-indol-3-yl)(thiophen-2-yl)methanone
• CAS NO: 1215004-65-1
• Molecular Weight: 303.384
• Mol File: 1215004-65-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2-phenyl-1H-indol-3-yl)(thiophen-2-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-phenyl-1H-indol-3-yl)(thiophen-2-yl)methanone(1215004-65-1)
• EPA Substance Registry System: (2-phenyl-1H-indol-3-yl)(thiophen-2-yl)methanone(1215004-65-1)

Safety Data

• Hazardous Substances Data: 1215004-65-1(Hazardous Substances Data)

Upstream product

• 29683-77-0 2-chloro-1-(thiophen-2-yl)ethanone 
• 1527-91-9 N-phenylbenzamidine 
• 1215004-54-8 (E)-3-(benzotriazol-1-yl)-2-(t-butyl)-3-phenyl-1-(thiophen-2-yl)prop-2-en-1-one 

Relevant articles and documents

Palladium-catalyzed cyclization reaction of N-(2-Haloaryl)alkynylimines: Synthesis of 3-acylindoles using water as the sole solvent and oxygen source

A simple and efficient strategy for the preparation of 3-acylindoles via palladium-catalyzed cyclization reaction of N-(2-haloaryl)alkynylimines in water has been developed. The reaction tolerates a wide range of functional groups, and the corresponding 3-acylindoles were obtained in high yields using water as the sole solvent and oxygen sources. Additionally, this method could provide a short synthesis route for Pravadoline, a phase II analgesic drug.

Practical method for synthesis of 2,3-disubstituted indole derivatives promoted by β-(benzotriazol-1-yl)allylic O-stannyl ketyl radicals

Treatment of β-aryl-β-(benzotriazol-1-yl)-α-primary alkyl (or aryl)-α,β-unsaturated ketones 1 with n-Bu3SnH (4 equiv) in a catalytic amount of AIBN in PhH at reflux afforded 3-alkyl (or aryl)-2-arylindoles 8 in good yields. However, when tert-butyl group is bonded at α-position, 3-acyl (or aroyl)-2-arylindoles 9 were obtained as major products along with phenanthridines 5 as minor products.