1215072-68-6Relevant articles and documents
Novel estrone mimetics with high 17β-HSD1 inhibitory activity
Oster, Alexander,Klein, Tobias,Werth, Ruth,Kruchten, Patricia,Bey, Emmanuel,Negri, Matthias,Marchais-Oberwinkler, Sandrine,Frotscher, Martin,Hartmann, Rolf W.
experimental part, p. 3494 - 3505 (2010/10/19)
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of estrone into estradiol, which is the most potent estrogen in humans. Lowering intracellular estradiol concentration by inhibition of this enzyme is a promising new option for th