1215097-54-3

Basic information

• Product Name: C₃₇H₂₄O₈
• CAS NO: 1215097-54-3
• Molecular Weight: 596.593
• Mol File: 1215097-54-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₂₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₂₄O₈(1215097-54-3)
• EPA Substance Registry System: C₃₇H₂₄O₈(1215097-54-3)

Safety Data

• Hazardous Substances Data: 1215097-54-3(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 600-76-0 brazilein 

Relevant articles and documents

Antitumor agents. 271: Total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents

The first total synthesis of the naturally occurring tetracyclic homoisoflavonoid brazilein (1) and 14 new analogs (1a-n) is reported. Target compounds and intermediates were assayed for anti-inflammatory effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB, and for cytotoxic activity against nasopharyngeal (KB), vincristine-resistant nasopharyngeal (KBvin), lung (A549) and prostate (DU-145) human cancer cell lines. The most active compound 1b showed potent effects on superoxide anion generation and elastase release with IC50 values of 1.2 and 1.9 μM, respectively, and was 65 times more potent than phenylmethylsulfonyl fluoride (PMSF), the positive control, in the latter assay. Additionally, 1b exhibited broad spectrum in vitro anticancer activity with IC50 values of 6-11 μM against the four tested cancer cell lines.